Labbé A, Khammari C, Baudouin C
Service d'Ophtalmologie III, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France.
J Fr Ophtalmol. 2007 Jun;30(6):631-46. doi: 10.1016/s0181-5512(07)89673-2.
The wound healing response is one of the major determinants of filtering surgery success. Over the last two decades, antifibrotic agents, 5-fluorouracil (5-FU) and mitomycin C (MMC), have modified the prognosis of filtering surgery, particularly in patients at high risk for failure. Nevertheless, these agents are associated with severe complications. In order to maximize their benefits and minimize the rate of complications, the use of these powerful treatments has to be carefully evaluated in relation to patient risk factors for scarring. The choice of an antifibrotic agent, mode, dose and duration of application should be made with complete knowledge of the different effects of these treatments and adapted for each patient after an exhaustive preoperative evaluation.
伤口愈合反应是滤过性手术成功的主要决定因素之一。在过去二十年中，抗纤维化药物5-氟尿嘧啶（5-FU）和丝裂霉素C（MMC）改变了滤过性手术的预后，尤其是在高失败风险患者中。然而，这些药物与严重并发症相关。为了使它们的益处最大化并降低并发症发生率，必须根据患者的瘢痕形成风险因素仔细评估这些强效治疗的使用。抗纤维化药物的选择、应用方式、剂量和持续时间应在全面了解这些治疗的不同效果的情况下做出，并在详尽的术前评估后针对每位患者进行调整。
