Pickhardt P J, Yagan N, Siegel M J, Balfe D M, Rothbaum R J
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Radiology. 1998 Mar;206(3):725-30. doi: 10.1148/radiology.206.3.9494492.
To determine the computed tomographic (CT) findings that are indicative of bowel disease in patients with cystic fibrosis.
CT scans in patients with cystic fibrosis were retrospectively reviewed for evidence of colonic abnormalities, including wall thickening, mural striation, fatty proliferation of the mesentery, and soft-tissue infiltration of pericolonic fat.
Ten patients with colonic abnormalities on CT scans (case patients) and 16 patients with normal CT results (cohort patients) were identified. Colonic abnormalities in case patients included wall thickening (mean thickness, 6.4 mm) and mesenteric infiltration in all, increased pericolonic fat in six, and mural striation in five. The right colon was involved in all case patients; contiguous extension involved the transverse colon in five, the descending colon in two, and all segments in one. Wall thickness in cohort patients was less than 2 mm. Eight case patients had abdominal pain; one had bloody diarrhea. Histopathologic examination results included nonspecific mucosal inflammation in four case patients, wall edema in one, and no abnormality in one. No patient had identifiable infectious colitis, colonic stricture, bowel obstruction, fibrosis, or Crohn disease. Mean dose of pancreatic enzyme replacement was similar in both groups.
Proximal colonic wall thickening without stricture, pericolonic fat proliferation, and mesenteric infiltration are CT findings of colonic disease associated with cystic fibrosis.
确定可提示囊性纤维化患者肠道疾病的计算机断层扫描（CT）表现。
回顾性分析囊性纤维化患者的CT扫描结果，以寻找结肠异常的证据，包括肠壁增厚、壁内条纹、肠系膜脂肪增生以及结肠周围脂肪的软组织浸润。
确定了10例CT扫描显示结肠异常的患者（病例组）和16例CT结果正常的患者（对照组）。病例组的结肠异常包括所有患者均有肠壁增厚（平均厚度6.4mm）和肠系膜浸润，6例患者结肠周围脂肪增加，5例患者有壁内条纹。所有病例组患者的右结肠均受累；连续扩展累及横结肠5例、降结肠2例、全段结肠1例。对照组患者的肠壁厚度小于2mm。8例病例组患者有腹痛；1例有血性腹泻。组织病理学检查结果包括4例病例组患者为非特异性黏膜炎症，1例为肠壁水肿，1例无异常。无患者患有可识别的感染性结肠炎、结肠狭窄、肠梗阻、纤维化或克罗恩病。两组患者的胰腺酶替代平均剂量相似。
近端结肠壁增厚但无狭窄、结肠周围脂肪增生和肠系膜浸润是与囊性纤维化相关的结肠疾病的CT表现。
