Hultborn R, Hanson C, Köpf I, Verbiené I, Warnhammar E, Weimarck A
Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden.
Anticancer Res. 1997 Nov-Dec;17(6D):4293-7.
Klinefelter's syndrome (KS, XXY) as a risk factor for developing breast cancer was evaluated in a retrospective study of 93 unselected male breast cancer patients from the Healthcare region of Western Sweden. Archival normal material from lymph nodes or skin and subcutaneous tissue was examined using the FISH (fluorescence in situ hybridisation)-technique. The best yield of intact nuclei was obtained from lymph node tissue. The prevalence rate of KS in males with breast cancer was found to be 7.5 per cent, a much higher rate than previously reported (approximately 3 per cent). Methodological differences are suggested to cause the increased prevalence rate. Based on our finding and on the prevalence of KS in the normal population as well as on the incidence of MBC, a 50-fold increased risk of developing breast cancer in males with KS relative to normal males was found. The same median age at diagnosis, 72 years, was established for both groups of patients. No differences in survival were seen.
在一项对瑞典西部医疗保健地区93名未经挑选的男性乳腺癌患者的回顾性研究中，评估了克氏综合征（KS，XXY）作为患乳腺癌风险因素的情况。使用荧光原位杂交（FISH）技术检查来自淋巴结或皮肤及皮下组织的存档正常材料。从淋巴结组织中获得完整细胞核的成功率最高。发现男性乳腺癌患者中KS的患病率为7.5%，远高于先前报道的患病率（约3%）。提示方法学差异导致了患病率的增加。基于我们的研究结果、KS在正常人群中的患病率以及男性乳腺癌（MBC）的发病率，发现患有KS的男性患乳腺癌的风险相对于正常男性增加了50倍。两组患者的诊断中位年龄均为72岁。未观察到生存差异。
