Lakhan Shaheen E, Vieira Karen F
Global Neuroscience Initiative Foundation, Los Angeles, CA, USA.
Nutr J. 2008 Jan 21;7:2. doi: 10.1186/1475-2891-7-2.
According to the Diagnostic and Statistical Manual of Mental Disorders, 4 out of the 10 leading causes of disability in the US and other developed countries are mental disorders. Major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder (OCD) are among the most common mental disorders that currently plague numerous countries and have varying incidence rates from 26 percent in America to 4 percent in China. Though some of this difference may be attributable to the manner in which individual healthcare providers diagnose mental disorders, this noticeable distribution can be also explained by studies which show that a lack of certain dietary nutrients contribute to the development of mental disorders. Notably, essential vitamins, minerals, and omega-3 fatty acids are often deficient in the general population in America and other developed countries; and are exceptionally deficient in patients suffering from mental disorders. Studies have shown that daily supplements of vital nutrients often effectively reduce patients' symptoms. Supplements that contain amino acids also reduce symptoms, because they are converted to neurotransmitters that alleviate depression and other mental disorders. Based on emerging scientific evidence, this form of nutritional supplement treatment may be appropriate for controlling major depression, bipolar disorder, schizophrenia and anxiety disorders, eating disorders, attention deficit disorder/attention deficit hyperactivity disorder (ADD/ADHD), addiction, and autism. The aim of this manuscript is to emphasize which dietary supplements can aid the treatment of the four most common mental disorders currently affecting America and other developed countries: major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder (OCD). Most antidepressants and other prescription drugs cause severe side effects, which usually discourage patients from taking their medications. Such noncompliant patients who have mental disorders are at a higher risk for committing suicide or being institutionalized. One way for psychiatrists to overcome this noncompliance is to educate themselves about alternative or complementary nutritional treatments. Although in the cases of certain nutrients, further research needs to be done to determine the best recommended doses of most nutritional supplements, psychiatrists can recommend doses of dietary supplements based on previous and current efficacious studies and then adjust the doses based on the results obtained.
根据《精神疾病诊断与统计手册》,在美国和其他发达国家,十大致残原因中有四项是精神障碍。重度抑郁症、双相情感障碍、精神分裂症和强迫症(OCD)是目前困扰众多国家的最常见精神障碍,发病率各不相同,在美国为26%,在中国为4%。虽然这种差异部分可能归因于个体医疗保健提供者诊断精神障碍的方式,但这种显著的分布差异也可以通过研究来解释,这些研究表明,某些膳食营养素的缺乏会导致精神障碍的发展。值得注意的是,必需维生素、矿物质和omega-3脂肪酸在美国和其他发达国家的普通人群中往往缺乏;而在患有精神障碍的患者中尤其缺乏。研究表明,每日补充重要营养素通常能有效减轻患者症状。含有氨基酸的补充剂也能减轻症状,因为它们会转化为缓解抑郁和其他精神障碍的神经递质。基于新出现的科学证据,这种营养补充剂治疗形式可能适用于控制重度抑郁症、双相情感障碍、精神分裂症和焦虑症、饮食失调、注意力缺陷障碍/注意力缺陷多动障碍(ADD/ADHD)、成瘾和自闭症。本文的目的是强调哪些膳食补充剂可以辅助治疗目前影响美国和其他发达国家的四种最常见精神障碍:重度抑郁症、双相情感障碍、精神分裂症和强迫症(OCD)。大多数抗抑郁药和其他处方药会引起严重的副作用,这通常会使患者不愿服药。这类患有精神障碍的不依从患者自杀或被送进精神病院的风险更高。精神科医生克服这种不依从的一种方法是了解替代或补充性营养治疗方法。虽然对于某些营养素,需要进一步研究以确定大多数营养补充剂的最佳推荐剂量,但精神科医生可以根据以往和当前的有效研究推荐膳食补充剂的剂量,然后根据获得的结果调整剂量。