Colavecchio Anna, Cadieux Brigitte, Lo Amanda, Goodridge Lawrence D
Food Safety and Quality Program, Department of Food Science and Agricultural Chemistry, McGill University, Ste-Anne-de-BellevueQC, Canada.
Front Microbiol. 2017 Jun 20;8:1108. doi: 10.3389/fmicb.2017.01108. eCollection 2017.
Foodborne illnesses continue to have an economic impact on global health care systems. There is a growing concern regarding the increasing frequency of antibiotic resistance in foodborne bacterial pathogens and how such resistance may affect treatment outcomes. In an effort to better understand how to reduce the spread of resistance, many research studies have been conducted regarding the methods by which antibiotic resistance genes are mobilized and spread between bacteria. Transduction by bacteriophages (phages) is one of many horizontal gene transfer mechanisms, and recent findings have shown phage-mediated transduction to be a significant contributor to dissemination of antibiotic resistance genes. Here, we review the viability of transduction as a contributing factor to the dissemination of antibiotic resistance genes in foodborne pathogens of the family, including non-typhoidal and Shiga toxin-producing , as well as environmental factors that increase transduction of antibiotic resistance genes.
食源性疾病继续对全球医疗保健系统产生经济影响。人们越来越关注食源性病原体中抗生素耐药性频率的增加，以及这种耐药性如何影响治疗结果。为了更好地理解如何减少耐药性的传播，已经开展了许多关于抗生素耐药基因在细菌之间转移和传播方式的研究。噬菌体转导是众多水平基因转移机制之一，最近的研究结果表明，噬菌体介导的转导是抗生素耐药基因传播的一个重要因素。在这里，我们综述了转导作为一个促成因素在肠杆菌科食源性病原体中抗生素耐药基因传播的可行性，包括非伤寒沙门氏菌和产志贺毒素大肠杆菌，以及增加抗生素耐药基因转导的环境因素。
