Chaudhuri A G, Bhattacharya J, Nair G B, Takeda T, Chakrabarti M K
National Institute of Cholera and Enteric Diseases, Beliaghata, Calcutta, India.
FEMS Microbiol Lett. 1998 Mar 1;160(1):125-9. doi: 10.1111/j.1574-6968.1998.tb12901.x.
The cytosolic calcium level ([Ca2+]i) and the membrane-bound guanylyl cyclase activity in the isolated rat intestinal epithelial cells were investigated. Heat-stable enterotoxin of Vibrio cholerae non-01 (NAG-ST) was found to increase both the [Ca2+]i and the enzyme activity. These changes occur similarly until 5 min of incubation with NAG-ST, indicating that these changes might be involved in NAG-ST induced signal transduction in rat enterocytes.
对分离出的大鼠肠上皮细胞中的胞质钙水平（[Ca2+]i）和膜结合鸟苷酸环化酶活性进行了研究。发现霍乱弧菌非01型热稳定肠毒素（NAG-ST）可同时提高[Ca2+]i和该酶的活性。在用NAG-ST孵育5分钟之前，这些变化的发生方式相似，这表明这些变化可能参与了NAG-ST诱导的大鼠肠细胞信号转导。
