Sonner J, Li J, Eger E I
Department of Anesthesia, University of California-San Francisco, 94143-0464, USA.
Anesth Analg. 1998 Mar;86(3):629-34. doi: 10.1097/00000539-199803000-00036.
Nonimmobilizers (previously called nonanesthetics) do not prevent movement in response to a noxious stimulus, even at doses predicted to produce anesthesia. We hypothesized they would also lack antinociceptive effects. We tested this prediction using the tail-flick latency (TFL) test. As predicted, the two nonimmobilizers tested (1,2-dichlorohexafluorocyclobutane and perfluoropentane) did not alter TFL, whereas desflurane and nitrous oxide both lengthened TFL (nitrous oxide at a lower minimum alveolar anesthetic concentration [MAC]-multiple than desflurane). In addition, we found that 0.1 MAC desflurane had a hyperalgesic effect (shortened TFL).
We studied the response of animals inhaling anesthetics or nonimmobilizers (compounds predicted to be anesthetics from the Meyer-Overton relation) to painful stimuli. Nonimmobilizers had no effect on these responses; at a low partial pressure, desflurane was hyperalgesic; nitrous oxide and, at higher partial pressures, desflurane were antinociceptive.
非麻醉性气体（以前称为非麻醉剂）即使在预计会产生麻醉效果的剂量下，也无法阻止动物对有害刺激做出的运动反应。我们推测它们也缺乏镇痛作用。我们使用甩尾潜伏期（TFL）试验来验证这一预测。正如预期的那样，所测试的两种非麻醉性气体（1,2 - 二氯六氟环丁烷和全氟戊烷）并未改变TFL，而地氟烷和氧化亚氮均延长了TFL（氧化亚氮在低于地氟烷的最低肺泡麻醉浓度[MAC]倍数时就有此作用）。此外，我们发现0.1 MAC的地氟烷具有痛觉过敏作用（缩短了TFL）。
我们研究了吸入麻醉剂或非麻醉性气体（根据迈耶 - 奥弗顿关系预测为麻醉剂的化合物）的动物对疼痛刺激的反应。非麻醉性气体对这些反应没有影响；在低分压下，地氟烷具有痛觉过敏作用；氧化亚氮以及在较高分压下地氟烷具有镇痛作用。
