Hof-Van Duin J V
Brain Res. 1976 Jul 30;111(2):261-76. doi: 10.1016/0006-8993(76)90771-x.
Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor behavior and pattern discrimination were tested before as well as after reverse closure, to compare performances of the deprived eye with those of the non-deprived eye. In order to get optimal visuomotor experience, the animals were kept in large playrooms for at least 4h each day. Except for normal tactile placing responses, visually triggered extension responses and uncertain jumping, 2 years after reverse closure all other tests (visually guided reaching, visual cliff behavior, obstacle avoidance, tracking, jumping, and visual blink responses) still showed impairments; the optokinetic nystagmus was asymmetric. In contrast with this partial behavioral recovery, pattern discrimination in a simple nose-push training box requiring no complicated visuomotor coordination was found to be positive. Discriminations of gratings of different orientations, starting 4 weeks after reverse closure, appeared to be normal, in comparison with performance using the non-deprived eye of the same cats tested before reverse closure. Form discrimination was also found to be positive; some monocularly deprived cats required more trails than normal cats in upright vs. reversed solid triangles discrimination, but succeeding form problems were mastered within the same range as found in normal cats. Apparently behavioral defects after monocular deprivation are due to deficiencies in visuomotor control rather than in pattern identification.
对一组出生后7 - 10天通过眼睑缝合单眼闭合饲养的猫进行了视觉运动行为和模式辨别研究。在8 - 10个月大时，通过反转眼闭合（闭合正常眼并睁开被剥夺的眼）迫使动物使用其被剥夺的眼睛。在反转闭合之前和之后都对视觉运动行为和模式辨别进行了测试，以比较被剥夺眼与未被剥夺眼的表现。为了获得最佳的视觉运动体验，每天将动物置于大游戏室中至少4小时。除了正常的触觉放置反应、视觉触发的伸展反应和不确定的跳跃外，反转闭合2年后，所有其他测试（视觉引导的伸手、视觉悬崖行为、避障、跟踪、跳跃和视觉眨眼反应）仍显示受损；视动性眼球震颤不对称。与这种部分行为恢复形成对比的是，在一个不需要复杂视觉运动协调的简单推鼻训练箱中进行的模式辨别被发现是阳性的。与在反转闭合前测试的同一只猫的未被剥夺眼的表现相比，从反转闭合4周后开始，对不同方向光栅的辨别似乎是正常的。形状辨别也被发现是阳性的；一些单眼剥夺的猫在直立与反转实心三角形辨别中比正常猫需要更多的试验，但后续的形状问题在与正常猫相同的范围内得到掌握。显然，单眼剥夺后的行为缺陷是由于视觉运动控制不足而非模式识别不足。
