Raza J, Hindmarsh P C, Brook C G
London Centre for Paediatric Endocrinology, Great Ormond Street, Hospital for Children, London.
Arch Dis Child. 1997 Dec;77(6):526-7. doi: 10.1136/adc.77.6.526.
The rate of fall of serum thyroid stimulating hormone (TSH) concentrations in 32 hypothyroid infants (11 boys, 21 girls) was studied after starting treatment with thyroxine to determine whether it was influenced by initial TSH concentration or the cause of the hypothyroidism. Of 27 patients who had isotope scans before treatment was started, 11 (40%) were athyrotic, 10 (38%) had an ectopic gland, and six (22%) probably had dyshormonogenesis. Treatment was started with thyroxine at 100 micrograms/m2/24 hours at a mean age of 26 days (range 14-45). Serum TSH concentrations remained increased in 26 (81%) at 3 months, 20 (62.5%) at 6 months, and nine (28%) at 1 year and beyond. The mean age for serum TSH to reach the normal range was 0.79 years (range 0.15-2.1 years). Diagnosis (in 27 patients) and initial results (in 32) made no difference to the rate of fall.
对32名甲状腺功能减退婴儿（11名男孩，21名女孩）开始用甲状腺素治疗后血清促甲状腺激素（TSH）浓度的下降速率进行了研究，以确定其是否受初始TSH浓度或甲状腺功能减退病因的影响。在开始治疗前进行同位素扫描的27例患者中，11例（40%）为无甲状腺，10例（38%）有异位腺体，6例（22%）可能存在激素合成障碍。治疗从甲状腺素100微克/平方米/24小时开始，平均年龄为26天（范围14 - 45天）。3个月时，26例（81%）血清TSH浓度仍升高，6个月时20例（62.5%），1岁及以后9例（28%）。血清TSH达到正常范围的平均年龄为0.79岁（范围0.15 - 2.1岁）。诊断（27例患者）和初始结果（32例）对下降速率无影响。
