Smith J D, Chang K L, Gums J G
Department of Pharmacy Practice, University of Florida, Gainesville, USA.
Ann Pharmacother. 1998 Feb;32(2):196-200. doi: 10.1345/aph.17190.
To report a case of myalgia with eosinophilia related to lansoprazole administration.
A 50-year-old white woman developed severe myalgia 1 week after starting lansoprazole. During the treatment course, the patient was also found to have eosinophilia. The myalgia and eosinophilia resolved 40 days after lansoprazole was stopped and 18 days after prednisone therapy was begun. The patient was not rechallenged with lansoprazole.
To our knowledge, this is the first reported case of lansoprazole-induced eosinophilic syndrome. Clinically, it is difficult to distinguish between eosinophilia-myalgia syndrome and eosinophilic fasciitis, which are probably part of a continuum of eosinophilic disorders. This patient presented with symptoms of both syndromes. Although other causes cannot be completely ruled out, the time course strongly suggests that lansoprazole was the causative agent.
It is important to consider medications when diagnosing patients with hypereosinophilia and/or myalgia.
报告1例与兰索拉唑使用相关的嗜酸性粒细胞增多性肌痛病例。
一名50岁白人女性在开始使用兰索拉唑1周后出现严重肌痛。在治疗过程中，该患者还被发现有嗜酸性粒细胞增多。在停用兰索拉唑40天后以及开始泼尼松治疗18天后，肌痛和嗜酸性粒细胞增多症状消失。未让该患者再次使用兰索拉唑。
据我们所知，这是首例报告的兰索拉唑诱发的嗜酸性粒细胞综合征病例。临床上，嗜酸性粒细胞增多性肌痛综合征和嗜酸性筋膜炎很难区分，它们可能是嗜酸性粒细胞疾病连续谱的一部分。该患者同时出现了这两种综合征的症状。虽然不能完全排除其他病因，但时间进程强烈提示兰索拉唑是致病因素。
在诊断嗜酸性粒细胞增多和/或肌痛患者时，考虑药物因素很重要。
