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对MVA疫苗稳定性的贡献(作者译)

[A contribution to the stabilisation of the MVA-vaccine (author's transl)].

作者信息

Just I, Finke H

出版信息

Zentralbl Bakteriol Orig A. 1979;245(3):276-82.

PMID:94967
Abstract

The titre of the MVA-vaccine remains constant at -20 degrees C with human serum albumin, sorbitol, Haemaccel, Rheomacrodex and cysteine within 8 month. At -20 degrees C the stability of the MVA-virus is equivalent to the Vaccinia-virus, stabilized by peptone and sorbitol. Storing the MVA-Virus at +4 degrees C, +20 degrees C for 8 month or at 27 degrees C for 4 weeks, 1% human serum albumin and 5% sorbitol preserves the virustitre best, but the stability of Vaccinia-virus with 5% peptone and 5% sorbitol can, however, not be obtained by the MVA-virus under these conditions.

摘要

MVA疫苗在-20℃下与人类血清白蛋白、山梨醇、贺斯、聚明胶肽和半胱氨酸共同保存8个月时,效价保持恒定。在-20℃下,MVA病毒的稳定性与通过蛋白胨和山梨醇稳定化的痘苗病毒相当。将MVA病毒在+4℃、+20℃下保存8个月或在27℃下保存4周时,1%的人类血清白蛋白和5%的山梨醇对病毒效价的保存效果最佳,但在这些条件下,MVA病毒无法达到5%蛋白胨和5%山梨醇对痘苗病毒的稳定效果。

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Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants?可否用 MVA 病毒替代牛痘病毒来测试化学消毒剂的杀病毒活性?
BMC Infect Dis. 2010 Jun 23;10:185. doi: 10.1186/1471-2334-10-185.
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