Benedetto C, Allais G, Ciochetto D, De Lorenzo C
Woman's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Torino, Italy.
Cephalalgia. 1997 Dec;17 Suppl 20:32-4. doi: 10.1177/0333102497017S2010.
We review the role of several biochemical and hormonal factors in menstrual migraine pathogenesis: ovarian hormones, aldosterone circadian rhythm, nocturnal urinary melatonin excretion, sympathetic autonomic system, prolactin levels and dopaminergic function, endogenous opioid tonus, platelet activity and arachidonic acid metabolites. In particular, we focus on certain aspects of platelet function and prostaglandin metabolism, taking into consideration the different behavior of platelet sensitivity to prostacyclin, intraplatelet 5HT, peripheral plasma concentrations of 6-keto-PGF1alpha and PGE2 in menstrual migraine sufferers and in control subjects during the menstrual cycle. A comprehensive view of the data suggests that a complex impairment of PG and 5HT metabolism, and of platelet function, may play a significant role in the pathogenesis of menstrual migraine. However, it is not yet clear whether these alterations are primary or secondary to neuroendocrine disorders.
卵巢激素、醛固酮昼夜节律、夜间尿褪黑素排泄、交感自主神经系统、催乳素水平和多巴胺能功能、内源性阿片类张力、血小板活性和花生四烯酸代谢产物。特别是，我们关注血小板功能和前列腺素代谢的某些方面，考虑到月经性偏头痛患者和对照受试者在月经周期中血小板对前列环素的敏感性、血小板内5-羟色胺、外周血浆6-酮-前列腺素F1α和前列腺素E2浓度的不同表现。对数据的综合分析表明，PG和5-羟色胺代谢以及血小板功能的复杂损害可能在月经性偏头痛的发病机制中起重要作用。然而，这些改变是神经内分泌紊乱的原发性还是继发性尚不清楚。
