体重不足1000克的早产儿的麻疹、腮腺炎和风疹血清学检测
Measles, mumps, and rubella serology in premature infants weighing less than 1,000 grams.
作者信息
Glick C, Feldman S, Norris M R, Butler J
机构信息
Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
出版信息
South Med J. 1998 Feb;91(2):159-60. doi: 10.1097/00007611-199802000-00008.
BACKGROUND
This study was done to determine antibodies to measles, mumps, and rubella within the first 2 weeks of life and 3 months of age in premature infants.
METHODS
All premature infants (< 32 weeks' gestation) weighing less than 1,000 g and admitted to the neonatal intensive care unit were eligible for inclusion in the study. Measles, mumps, and rubella titers were obtained from the mother and from the infant during the first 2 weeks of life and at 3 months of age.
RESULTS
A total of 44 maternal-infant pairs were enrolled. At birth, 45% of the infants were seronegative for measles, 55% for mumps, and 48% for rubella. Maternal samples revealed seronegativity in 14%, 3%, and 17%, respectively. By 3 months of age, 100% of infants were seronegative for mumps and rubella, and 94% were seronegative for measles.
CONCLUSIONS
The majority of prematurely born infants are seronegative for measles, mumps, and rubella by 3 months of age and therefore are presumably susceptible to infection during the first year of life.
背景
本研究旨在确定早产儿出生后2周内及3月龄时麻疹、腮腺炎和风疹抗体情况。
方法
所有孕周小于32周、体重小于1000克且入住新生儿重症监护病房的早产儿均符合纳入本研究的条件。在出生后2周内及3月龄时获取母亲及婴儿的麻疹、腮腺炎和风疹抗体滴度。
结果
共纳入44对母婴。出生时，45%的婴儿麻疹血清学阴性，55%腮腺炎血清学阴性，48%风疹血清学阴性。母亲样本中，麻疹、腮腺炎和风疹血清学阴性率分别为14%、3%和17%。到3月龄时，100%的婴儿腮腺炎和风疹血清学阴性，94%的婴儿麻疹血清学阴性。
结论
大多数早产儿在3月龄时麻疹、腮腺炎和风疹血清学阴性，因此在出生后第一年可能易感染这些疾病。
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