胃内给予β-内啡肽对大鼠促甲状腺激素释放激素和生长抑素释放至胃腔的影响。
Effect of intragastric administration of beta-endorphin on thyrotropin-releasing hormone and somatostatin release into gastric lumen of rats.
作者信息
Konagaya T, Kusugami K, Yamamoto H, Nishio Y, Kaneko H, Nagai H, Mitsuma T
机构信息
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
出版信息
J Gastroenterol. 1998 Feb;33(1):27-31. doi: 10.1007/pl00009963.
The neuropeptides beta-endorphin (BE), thyrotropin-releasing hormone (TRH), and somatostatin (SOM) in the gastric mucosa have the capacity to regulate gastric function. To clarify the possible role of BE in the interactions of neuropeptides and gastric acid secretion we investigated the effect of the intragastric administration of BE on TRH and SOM release into the gastric lumen. BE (100ng/kg) induced an immediate decrease in TRH release and a reciprocal increase in SOM release into the gastric lumen, followed by the suppression of gastric acid secretion. When various doses of BE (0-500ng/kg) were administered, changes in TRH and SOM occurred in a dose-dependent manner. Pretreatment with naloxone dihydrochloride (5 mg/kg, intraperitoneally) completely inhibited the BE-induced changes in the release of these peptides. These findings suggest that BE has a paracrine effect on TRH and SOM release into the gastric lumen through opioid receptors, and that these interactions may be involved in the regulation of gastric acid secretion.
胃黏膜中的神经肽β-内啡肽（BE）、促甲状腺激素释放激素（TRH）和生长抑素（SOM）具有调节胃功能的能力。为了阐明BE在神经肽相互作用及胃酸分泌中的可能作用，我们研究了胃内给予BE对TRH和SOM释放到胃腔中的影响。BE（100ng/kg）可使TRH释放立即减少，同时SOM释放到胃腔中相应增加，随后胃酸分泌受到抑制。当给予不同剂量的BE（0 - 500ng/kg）时，TRH和SOM的变化呈剂量依赖性。腹腔注射盐酸纳洛酮（5mg/kg）预处理可完全抑制BE诱导的这些肽释放的变化。这些发现表明，BE通过阿片受体对TRH和SOM释放到胃腔具有旁分泌作用，并且这些相互作用可能参与胃酸分泌的调节。
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