Zahran F M, el-Arab A E, Raafat I
Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University.
Egypt Dent J. 1995 Oct;41(4):1363-6.
Mounting evidence points out to the immunologic basis of lichen planus (LP). Tumour necrosis factor (TNF-alpha) is a cytokine with multiple biologic activities, some of which may be relevant to the pathogenesis of LP. The present study was thus conducted to assess its production by peripheral blood leucocytes in patients with active lesions of oral lichen planus (OLP) compared to age matched healthy control volunteers. For the assessment, the quantitative immunometric sandwich technique was employed. Significantly greater amounts of TNF-alpha were found in serum samples of OLP patients compared to healthy individuals, suggesting a possible association between this cytokine and the pathogenesis of OLP and pointing out to the primary initiative role played by altered keratinocytes. This pointed out the beneficial effect of anti-TNF drugs in the management of OLP.
越来越多的证据表明扁平苔藓（LP）存在免疫基础。肿瘤坏死因子（TNF-α）是一种具有多种生物学活性的细胞因子，其中一些活性可能与LP的发病机制相关。因此，本研究旨在评估与年龄匹配的健康对照志愿者相比，口腔扁平苔藓（OLP）活动期患者外周血白细胞产生TNF-α的情况。为进行评估，采用了定量免疫分析夹心技术。与健康个体相比，OLP患者血清样本中发现的TNF-α量显著更高，这表明该细胞因子与OLP发病机制之间可能存在关联，并指出角质形成细胞改变所起的主要起始作用。这表明抗TNF药物在OLP治疗中具有有益效果。
