Granlund H, Erkko P, Reitamo S
Department of Dermatology, Helsinki University Central Hospital, Finland.
Acta Derm Venereol. 1998 Jan;78(1):40-3. doi: 10.1080/00015559850135814.
Cyclosporine is efficacious in short-term treatment of various eczematous disorders. In a follow-up study we have evaluated the long-term efficacy of cyclosporine in 75 patients, who in previous studies had been treated with cyclosporine for chronic actinic dermatitis (6 patients), atopic dermatitis (42 patients) and chronic hand eczema (27 patients), 4, 2 and 1 year after the initial treatment, respectively. Three out of 6 patients with chronic actinic dermatitis showed long-term efficacy. Two years after the initial treatment with cyclosporine (5 mg/kg/day for 1-2 treatment periods of 6 weeks) for atopic dermatitis the mean disease activity was significantly lower compared to baseline (58% decrease), and compared to the time of treatment stop no significant change had occurred. Of 37 evaluable patients 35 were still in remission. One year after the initial treatment with cyclosporine (3 mg/kg/day for 6 weeks) for chronic hand eczema the mean disease activity was significantly lower than at baseline (54% decrease), and compared to the time of treatment stop no significant change had occurred. Of 27 evaluable patients 21 patients were still in remission. The study suggests that long-term remissions are possible in eczematous diseases treated with cyclosporine, even for a relatively short treatment period. It must be stressed, however, that we did not have control groups for any of the studied patient groups.
环孢素在各种湿疹性疾病的短期治疗中有效。在一项随访研究中，我们评估了环孢素对75例患者的长期疗效，这些患者在之前的研究中分别因慢性光化性皮炎（6例）、特应性皮炎（42例）和慢性手部湿疹（27例）接受过环孢素治疗，初始治疗后分别随访4年、2年和1年。6例慢性光化性皮炎患者中有3例显示出长期疗效。用环孢素（5mg/kg/天，为期1 - 2个6周疗程）治疗特应性皮炎2年后，平均疾病活动度与基线相比显著降低（降低58%），与治疗停止时相比无显著变化。在37例可评估患者中，35例仍处于缓解期。用环孢素（3mg/kg/天，为期6周）治疗慢性手部湿疹1年后，平均疾病活动度显著低于基线（降低54%），与治疗停止时相比无显著变化。在27例可评估患者中，21例仍处于缓解期。该研究表明，即使治疗期相对较短，用环孢素治疗的湿疹性疾病也可能实现长期缓解。然而，必须强调的是，我们对任何研究的患者组均未设置对照组。
