Fiscus S A, Hughes M D, Lathey J L, Pi T, Jackson B, Rasheed S, Elbeik T, Reichman R, Japour A, Byington R, Scott W, Griffith B P, Katzenstein D A, Hammer S M
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599-7140, USA.
J Infect Dis. 1998 Mar;177(3):625-33. doi: 10.1086/514248.
The associations of CD4 cell count, plasma human immunodeficiency virus (HIV) type 1 RNA, infectious HIV titer in peripheral blood mononuclear cells, immune complex-disrupted (ICD) p24 antigen, and MT-2 assays with measures of disease progression after drug treatment were assessed in a subset of patients enrolled in AIDS Clinical Trials Group Study 175. Baseline plasma RNA levels and changes in RNA values at weeks 8 or 56 were more important predictors of disease progression than were baseline or changes in CD4 cell counts. Each 10-fold lower HIV RNA concentration at baseline and each 10-fold decrease in HIV RNA between baseline and week 8 was associated with increases of 49-61 CD4 cells/mm3 at weeks 56 and 104. In multivariate analyses, neither baseline values nor changes in infectious HIV titer nor ICD p24 antigen concentrations were associated with long-term changes in CD4 cell count. Plasma HIV-1 RNA appears to be the best predictor of long-term CD4 cell count responses and disease progression.
在参加艾滋病临床试验组研究175的一部分患者中，评估了CD4细胞计数、血浆1型人类免疫缺陷病毒（HIV）RNA、外周血单核细胞中具有传染性的HIV滴度、免疫复合物破坏（ICD）的p24抗原以及MT-2检测与药物治疗后疾病进展指标之间的关联。与基线或CD4细胞计数变化相比，基线血浆RNA水平以及第8周或第56周时RNA值的变化是疾病进展更重要的预测指标。基线时HIV RNA浓度每降低10倍以及基线至第8周期间HIV RNA每降低10倍，均与第56周和第104周时CD4细胞增加49 - 61个/mm³相关。在多变量分析中，基线值、具有传染性的HIV滴度变化以及ICD p24抗原浓度均与CD4细胞计数的长期变化无关。血浆HIV-1 RNA似乎是长期CD4细胞计数反应和疾病进展的最佳预测指标。
