Martín Carballo G, Fernández Cano G, Grande Aragón C, Méndez Alavedra J, Hawkins Carranza F, Gracia Bouthelier R
Servicio de Endocrinología, Hospital Infantil La Paz, Madrid.
An Esp Pediatr. 1997 Sep;47(3):295-301.
The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood.
A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out.
The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.
本研究的目的是确定糖尿病母亲所生婴儿（IDM）巨大儿的发生率，并分析其与脐带血中胰岛素、C肽、生长激素（GH）和IGF-I水平的可能相关性。
对58例IDM和58例对照新生儿（两组均为33例男性和25例女性）进行了前瞻性研究。
IDM组巨大儿发生率为25.8%，胰岛素依赖型糖尿病母亲所生婴儿（IIDDM组）为61.5%，而对照组为5%。IDM组（尤其是IIDDM组）妊娠晚期母亲糖化血红蛋白A1c水平与胰岛素和C肽水平与新生儿体重呈正相关。对照组和IDM组中IGF-I水平均与新生儿体重呈正相关。任何组中GH和IGF-I水平之间均无相关性。
