Brumaghim J T, Klorman R
Department of Clinical and Social Sciences in Psychology, University of Rochester, NY 14627, USA.
Psychophysiology. 1998 Jan;35(1):73-85.
The effects of methylphenidate (0.3 mg/kg) on young adults paired-associate learning (PAL) of consonant-vowel-consonant (CVC) pairs and concomitant event-related potentials were assessed. The stimulant elevated mood and heart rate but did not affect PAL performance. For the first CVC, there were amplitude increases with learning for P3b at Pz, P2 at midline sites, and for a negative slow wave at Cz. For the second CVC, P3b and positive slow wave amplitude declined with learning. Increases in P3b amplitude to the first CVC were attributed to increments in stimulus meaningfulness. Decreases in P3b amplitude to the second CVC were interpreted as resulting from fewer disconfirmed expectations of feedback. The negative slow wave following the first CVC was viewed as a contingent negative variation. Methylphenidate increased parietal P3b amplitude for CVC 2, averaged over learning phases.
评估了哌甲酯（0.3毫克/千克）对年轻成年人辅音-元音-辅音（CVC）对的配对联想学习（PAL）及伴随的事件相关电位的影响。该兴奋剂提升了情绪和心率，但未影响PAL表现。对于第一个CVC，在Pz处的P3b、中线部位的P2以及Cz处的负向慢波，其振幅随学习增加。对于第二个CVC，P3b和正向慢波振幅随学习下降。第一个CVC的P3b振幅增加归因于刺激意义性的增加。第二个CVC的P3b振幅下降被解释为反馈的未证实期望减少所致。第一个CVC之后的负向慢波被视为一种关联性负变化。在学习阶段平均后，哌甲酯增加了CVC 2的顶叶P3b振幅。
