Jensen M D, Levine J
Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
Metabolism. 1998 Mar;47(3):280-4. doi: 10.1016/s0026-0495(98)90257-8.
These studies examined whether women using oral contraceptives have abnormalities in free fatty acid (FFA) metabolism compared with women not using oral contraceptives. Plasma palmitate kinetics ([3H]palmitate) were measured at rest, following glucose ingestion, and during epinephrine infusion in 13 oral contraceptive users and 13 matched women not using oral contraceptives. Oral contraceptive users had significantly greater plasma triglyceride concentrations and glucose responses to oral glucose tolerance testing. No differences in basal (2.1 +/- 0.1 v 1.8 +/- 0.2 micromol x kg fat-free mass x FFM(-1) x min[-1]), glucose-suppressed (0.6 +/- 0.1 v 0.5 +/- 0.1 micromol x kg FFM(-1) x min[-1]), or epinephrine-stimulated (3.3 +/- 0.1 v 3.6 +/- 0.2 micromol x kg FFM(-1) x min[-1]) palmitate flux were detected between women using and not using oral contraceptives. The respiratory quotient (RQ) also was not different between groups. We conclude that the increase in plasma triglycerides and the mild glucose intolerance seen with oral contraceptive use is not associated with significant abnormalities of FFA metabolism.
这些研究探讨了与未使用口服避孕药的女性相比，使用口服避孕药的女性在游离脂肪酸（FFA）代谢方面是否存在异常。在13名口服避孕药使用者和13名匹配的未使用口服避孕药的女性中，分别于静息状态、摄入葡萄糖后以及肾上腺素输注期间测量了血浆棕榈酸动力学（[3H]棕榈酸）。口服避孕药使用者的血浆甘油三酯浓度以及口服葡萄糖耐量试验的血糖反应显著更高。在基础状态（2.1±0.1对1.8±0.2微摩尔×千克去脂体重×FFM（-1）×分钟（-1））、葡萄糖抑制状态（0.6±0.1对0.5±0.1微摩尔×千克FFM（-1）×分钟（-1））或肾上腺素刺激状态（3.3±0.1对3.6±0.2微摩尔×千克FFM（-1）×分钟（-1））下，未检测到使用和未使用口服避孕药的女性之间棕榈酸通量存在差异。两组之间的呼吸商（RQ）也没有差异。我们得出结论，使用口服避孕药时出现的血浆甘油三酯升高和轻度葡萄糖不耐受与FFA代谢的显著异常无关。
