Bryan C F, Mitchell S I, Lin H M, Nelson P W, Shield C F, Luger A M, Pierce G E, Ross G, Warady B A, Aeder M I, Helling T S, Landreneau M D, Harrell K M
Midwest Organ Bank, Inc., Westwood, Kansas 66205, USA.
Transplantation. 1998 Feb 27;65(4):588-92. doi: 10.1097/00007890-199802270-00026.
The Rh (D) blood group system has not traditionally been considered to be a clinically relevant histocompatibility barrier in transplantation since conflicting results of its clinical importance have been reported.
We analyzed 786 consecutive primary cadaveric renal transplants performed by transplant centers in our Organ Procurement Organization (OPO) between 1990 and 1997. We also analyzed United Network for Organ Sharing (UNOS) data on 26,469 kidney transplants done from April 1994 to June 1996.
Multivariate analysis revealed that Rh identity between the recipient and donor was significantly related to better graft outcome (risk ratio, 0.43; 95% confidence interval, 0.30 to 0.61; P=0.0001). Multivariate analysis of the UNOS data revealed that the Rh -/- group may have a positive influence on graft survival with a risk ratio of 0.43 (P=0.14).
Multivariate analysis of primary cadaveric renal allografts performed within the Midwest Organ Bank OPO indicates that Rh (D) is a clinically relevant histocompatibility barrier that influences 7-year graft survival.
传统上，Rh（D）血型系统在移植中并未被视为具有临床相关性的组织相容性屏障，因为关于其临床重要性的报道结果相互矛盾。
我们分析了1990年至1997年间由我们器官采购组织（OPO）内的移植中心进行的786例连续原发性尸体肾移植。我们还分析了器官共享联合网络（UNOS）关于1994年4月至1996年6月期间进行的26469例肾移植的数据。
多变量分析显示，受者与供者之间的Rh血型匹配与更好的移植结果显著相关（风险比，0.43；95%置信区间，0.30至0.61；P = 0.0001）。对UNOS数据的多变量分析显示，Rh -/-组可能对移植存活有积极影响，风险比为0.43（P = 0.14）。
对中西部器官库OPO内进行的原发性尸体肾同种异体移植的多变量分析表明，Rh（D）是一个影响7年移植存活的具有临床相关性的组织相容性屏障。
