Takahashi M, Hoshii Y, Kawano H, Setoguchi M, Gondo T, Yamashita Y, Nakayasu K, Kamei T, Ishihara T
Department of Surgical Pathology, Yamaguchi University School of Medicine, Ube, Japan.
Am J Surg Pathol. 1998 Mar;22(3):360-7. doi: 10.1097/00000478-199803000-00012.
Pancreatic islet cell tumors, especially insulinomas, are often associated with amyloid deposition in the tumor tissue. Biochemical analysis has demonstrated that the amyloid protein from insulinoma is derived from islet amyloid polypeptide (or amylin) that is produced by tumor cells originating from beta cells of the islet of Langerhans. We examined a case of malignant pancreatic islet cell tumor with amyloid deposition in the tumor tissue using immunohistochemistry and double-labeling immunogold electron microscopy. The tumors were composed of cells producing multiple hormones, including somatostatin, gastrin, amylin, insulin, calcitonin gene-related polypeptide, and calcitonin. Amyloid deposits reacted with antisomatostatin antiserum but not with other antisera, including antiamylin. The present study demonstrated for the first time that amyloid associated with islet cell tumors is not always derived from amylin and can come from somatostatin.
胰岛细胞瘤，尤其是胰岛素瘤，常与肿瘤组织中的淀粉样沉积有关。生化分析表明，胰岛素瘤中的淀粉样蛋白来源于胰岛淀粉样多肽（或胰淀素），其由源自胰岛β细胞的肿瘤细胞产生。我们使用免疫组织化学和双标记免疫金电子显微镜检查了一例肿瘤组织中有淀粉样沉积的恶性胰岛细胞瘤。肿瘤由产生多种激素的细胞组成，包括生长抑素、胃泌素、胰淀素、胰岛素、降钙素基因相关肽和降钙素。淀粉样沉积物与抗生长抑素抗血清反应，但不与包括抗胰淀素在内的其他抗血清反应。本研究首次证明，与胰岛细胞瘤相关的淀粉样蛋白并非总是来源于胰淀素，也可能来自生长抑素。
