Ohsawa H, Kanatsuka A, Tokuyama Y, Yamaguchi T, Makino H, Yoshida S, Horie H, Mikata A, Kohen Y
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
Acta Endocrinol (Copenh). 1991 Jan;124(1):45-53. doi: 10.1530/acta.0.1240045.
Amyloid deposits in somatostatinomas are rare observations. To examine the characteristics of this amyloid, we compared amyloid deposits in a somatostatinoma to those found in pancreatic tissue in patients with Type II diabetes mellitus and in insulinomas, using immunohistochemical techniques and specific antibodies to islet amyloid polypeptide or other pancreatic hormones, as well as electron-microscopy. Antibodies to islet amyloid polypeptide regions 8-17 or 25-37 were confirmed to be specific. Amyloid deposits in patients with Type II diabetes mellitus and in insulinomas, but not those in the somatostatinoma strongly reacted with these antibodies, or to an antibody to amyloid P component. Amyloid deposits in the somatostatinoma were not reactive with antibodies to somatostatin or to other pancreatic hormones. Electron-microscopic examinations revealed that amyloid fibrils in the somatostatinoma were thinner and more randomly distributed than were those in islets from patients with Type II diabetes mellitus. As amyloid in somatostatinomas is unlike that consisting of islet amyloid polypeptide or other mature pancreatic hormones, it may be a novel type of local amyloid in pancreatic islets.
生长抑素瘤中的淀粉样沉积物是罕见的发现。为了研究这种淀粉样物质的特征，我们使用免疫组织化学技术和针对胰岛淀粉样多肽或其他胰腺激素的特异性抗体，以及电子显微镜，将生长抑素瘤中的淀粉样沉积物与2型糖尿病患者胰腺组织和胰岛素瘤中的淀粉样沉积物进行了比较。已证实针对胰岛淀粉样多肽8-17区或25-37区的抗体具有特异性。2型糖尿病患者和胰岛素瘤中的淀粉样沉积物与这些抗体或淀粉样P成分抗体发生强烈反应，但生长抑素瘤中的淀粉样沉积物则不然。生长抑素瘤中的淀粉样沉积物与生长抑素或其他胰腺激素的抗体无反应。电子显微镜检查显示，生长抑素瘤中的淀粉样纤维比2型糖尿病患者胰岛中的淀粉样纤维更细且分布更随机。由于生长抑素瘤中的淀粉样物质不同于由胰岛淀粉样多肽或其他成熟胰腺激素组成的淀粉样物质，它可能是胰岛中一种新型的局部淀粉样物质。
