Menghini G, Pallotta B
Digestion. 1976;14(2):163-9. doi: 10.1159/000197921.
In a group of 16 patients, receiving chenic acid (20 mg/kg/day) and phenobarbital (60 mg/day) for gallstone dissolution, three patients were observed to develop a marked increase in serum levels of SGOT-SGPT and alkaline phosphatase without associated symptoms. Liver biopsy in one patient showed cellular infiltration with neutrophils and eosinophils, suggestive of a hypersensitivity reaction. Enzyme levels returned to normal, following cessation of chenotherapy, and a second biopsy 3 months later was normal. In that patient a challenge with chenic acid, at 250 mg/day, was again followed by a marked elevation in levels of SGOT-SGPT and alkaline phosphatase. These patients are the first to show marked elevation in liver enzyme levels during chenotherapy; the mechanism and significance are unclear.
在一组16例接受鹅去氧胆酸（20毫克/千克/天）和苯巴比妥（60毫克/天）进行胆结石溶解治疗的患者中，观察到3例患者血清谷草转氨酶-谷丙转氨酶和碱性磷酸酶水平显著升高，但无相关症状。其中1例患者的肝活检显示有中性粒细胞和嗜酸性粒细胞浸润，提示为过敏反应。停止利胆治疗后酶水平恢复正常，3个月后的第二次活检结果正常。在该患者中，再次给予250毫克/天的鹅去氧胆酸激发试验后，谷草转氨酶-谷丙转氨酶和碱性磷酸酶水平再次显著升高。这些患者是首例在利胆治疗期间肝酶水平显著升高的病例；其机制和意义尚不清楚。
