Matsuura K, Ikoma S, Yoshida K, Sinohara H
Department of Biochemistry, Kinki University School of Medicine, Osaka, Japan.
Biochem Biophys Res Commun. 1998 Feb 24;243(3):719-21. doi: 10.1006/bbrc.1998.8164.
Of 18 monoclonal Bence Jones proteins purified from urine of patients with multiple myeloma, 4 were found to have a DNA-nicking activity. In contrast, all Bence Jones proteins tested showed detectable amidase activity against carbobenzoxy-L-valyl-glycyl-L-arginine p-nitroanilide. No correlation between the two activities was found. Four patients excreting Bence Jones protein with the DNA-nicking activity showed somewhat severe symptoms, suggesting that this activity may be related to the progressive deterioration of clinical status.
