Meinwald J, Huang Q, Vrkoc J, Herath K B, Yang Z C, Schröder F, Attygalle A B, Iyengar V K, Morgan R C, Eisner T
Department of Chemistry, Cornell University, Ithaca, NY 14853, USA.
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2733-7. doi: 10.1073/pnas.95.6.2733.
The sunburst diving beetle, Thermonectus marmoratus, ejects a milky fluid from its prothoracic defensive glands when disturbed. Two major volatile components of this secretion are steroids; cybisterone (structure 7) constitutes about 20% of the volatiles, and a new steroid, mirasorvone, about 50%. Mirasorvone is assigned an 18-oxygenated pregnane structure (structure 9) on the basis of extensive spectroscopic data. Although no 18-oxygenated steroid has been described previously from an insect source, a closely related hormone with mineralocorticoid activity, 18-hydroxydeoxycorticosterone (structure 13), has been isolated from the adrenal glands of rats.
太阳爆纹潜水甲虫（Thermonectus marmoratus）受到干扰时会从其前胸防御腺中喷出一种乳白色液体。这种分泌物的两种主要挥发性成分是类固醇；环斑甾酮（结构7）约占挥发物的20%，一种新的类固醇，米拉斯沃酮，约占50%。基于广泛的光谱数据，米拉斯沃酮被确定为具有18-氧代孕烷结构（结构9）。尽管此前尚未从昆虫来源描述过18-氧代类固醇，但一种具有盐皮质激素活性的密切相关激素，18-羟基脱氧皮质酮（结构13），已从大鼠肾上腺中分离出来。
