Simister N E, Story C M
Rosenstiel Center for Basic Biomedical Sciences, W.M. Keck Institute for Cellular Visualization, Biology Department, Brandeis University, Waltham, MA 02254-9110, USA.
J Reprod Immunol. 1997 Dec 15;37(1):1-23. doi: 10.1016/s0165-0378(97)00068-5.
During human pregnancy, maternal IgG is transported across the placenta to the fetus. On the way, some maternal antibodies against fetal antigens are removed as immune complexes. The placenta contains several known Fc receptors and also other proteins that bind immunoglobulins. A consideration of the binding properties and distribution of these proteins suggests that the neonated Fc receptor (FcRn) transports IgG across the syncytiotrophoblast, and possibly the fetal blood vessel endothelium. Fc gamma RI, Fc gamma RII and Fc gamma RIII on Hofbauer cells in the stroma probably clear immune complexes, together with Fc gamma RII on endothelial cells.
在人类妊娠期间，母体IgG通过胎盘转运至胎儿体内。在此过程中，一些针对胎儿抗原的母体抗体作为免疫复合物被清除。胎盘含有几种已知的Fc受体以及其他能结合免疫球蛋白的蛋白质。对这些蛋白质的结合特性和分布进行研究后发现，新生儿Fc受体（FcRn）可将IgG转运穿过合体滋养层，也可能穿过胎儿血管内皮。基质中霍夫鲍尔细胞上的FcγRI、FcγRII和FcγRIII可能与内皮细胞上的FcγRII一起清除免疫复合物。
