新型冠状病毒感染后的垂直传播及母体被动免疫
Vertical transmission and maternal passive immunity post-SARS-CoV-2.
作者信息
Karimi Hanie, Mansouri Vahid, Rezaei Nima
机构信息
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran.
出版信息
Future Virol. 2023 Aug. doi: 10.2217/fvl-2023-0089. Epub 2023 Oct 4.
Abstract
Since 2020, the highly contagious nature and various transmission routes of SARS-CoV-2 have rendered the pandemic interminable. Vertical transmission (VT) through the placenta and breast milk, which is frequent for certain virus types, is thought to exist for SARS-CoV-2 and is hypothesized by many researchers. Conversely, antibodies are produced to counteract the effect of viruses. Since newborns' immunologic system cannot produce proper antibodies, maternal antibodies are usually transferred from mother to infant/fetus to meet the need. This theory leads to the hypothesis of transmission of antibodies through the placenta and breast milk following SARS-CoV-2 infection or vaccination. This paper further discusses these hypotheses, considering consequences of fetus/infant harm versus benefit.
摘要
自2020年以来，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的高传染性和多种传播途径使得这场大流行没完没了。某些病毒类型常见的通过胎盘和母乳的垂直传播（VT），被认为SARS-CoV-2也存在这种传播方式，许多研究人员对此进行了假设。相反，机体产生抗体以对抗病毒的作用。由于新生儿的免疫系统无法产生适当的抗体，母体抗体通常会从母亲转移到婴儿/胎儿以满足需求。这一理论引发了关于SARS-CoV-2感染或接种疫苗后抗体通过胎盘和母乳传播的假设。本文进一步讨论了这些假设，同时考虑了对胎儿/婴儿造成伤害与带来益处的后果。
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