Kamada Y, Oshiro N, Miyagi M, Oku H, Hongo F, Chinen I
Laboratories of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus, Okinawa, Japan.
Biosci Biotechnol Biochem. 1998 Jan;62(1):34-8. doi: 10.1271/bbb.62.34.
Further studies of mimosine toxicity in broiler chicks were done to clarify a possibility of osteopathy. The mineral content and density of femur and the strength, ductility, and toughness for the index of mechanical properties significantly decreased in the 1% mimosine group, compared with those in the control and restricted groups. The stiffness had a decreasing tendency in the 1% mimosine group. Consequently, it was concluded that chicks fed ad libitum a 1% mimosine diet for 12 days developed osteopathy. The bone mineral density and the strength of the restricted group were lower than those of the control group, and those of the 1% mimosine group were still lower than those of the restricted group. Contents of pyridinoline and deoxypyridinoline in the excrement were significantly higher in the restricted group than those in the control group, but the contents in the 1% mimosine group were significantly lowest among the groups. Osteopathy in chicks fed mimosine, therefore, seemed to be done by loss of appetite and changing to a low turnover of bone caused by mimosine.
为了阐明肉鸡患骨病的可能性，对含羞草素对肉鸡雏鸡的毒性进行了进一步研究。与对照组和限饲组相比，1%含羞草素组的股骨矿物质含量和密度以及机械性能指标的强度、延展性和韧性显著降低。1%含羞草素组的刚度有下降趋势。因此，得出结论，自由采食1%含羞草素日粮12天的雏鸡会患骨病。限饲组的骨矿物质密度和强度低于对照组，而1%含羞草素组的骨矿物质密度和强度仍低于限饲组。限饲组粪便中吡啶啉和脱氧吡啶啉的含量显著高于对照组，但1%含羞草素组的含量在各组中显著最低。因此，饲喂含羞草素的雏鸡患骨病似乎是由于食欲不振以及含羞草素导致的骨转换率降低所致。
