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[镁在支气管哮喘发病机制及治疗中的作用]

[The role of magnesium in the pathogenesis and therapy of bronchial asthma].

作者信息

Skotnicki A B, Jabłoński M J, Musiał J, Swadźba J

机构信息

Kliniki Hematologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.

出版信息

Przegl Lek. 1997;54(9):630-3.

PMID:9501684
Abstract

Magnesium is the fourth most abundant metal found in the body. It plays a crucial role in numerous biological processes. It is a natural calcium antagonist. New experimental data suggest that Mg+2 influences a variety of lung structures. Intracellular Mg+2 is thought to modulate smooth muscle contractions and it is known to have a direct effect on calcium uptake, resulting in smooth muscle relaxation. Magnesium has been forgotten cation from the therapeutical point of view, but now several clinical reports point to the salutary actions of Mg+2 in various lung diseases. Many reports suggests that magnesium sulfate and aspartate has certainly a role as an adjunct to traditional therapy in asthma and asthma-like conditions and have been helpful in the treatment of acute exacerbations of asthma.

摘要

镁是人体中含量第四丰富的金属。它在众多生物过程中发挥着关键作用。它是一种天然的钙拮抗剂。新的实验数据表明镁离子会影响多种肺部结构。细胞内的镁离子被认为可调节平滑肌收缩,并且已知其对钙摄取有直接影响,从而导致平滑肌松弛。从治疗角度来看,镁一直是被遗忘的阳离子,但现在有几份临床报告指出镁离子在各种肺部疾病中具有有益作用。许多报告表明硫酸镁和天冬氨酸在哮喘及类似哮喘病症中肯定可作为传统疗法的辅助手段,并且对哮喘急性加重的治疗有帮助。

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1
[The role of magnesium in the pathogenesis and therapy of bronchial asthma].[镁在支气管哮喘发病机制及治疗中的作用]
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The role of magnesium in lung diseases: asthma, allergy and pulmonary hypertension.镁在肺部疾病中的作用:哮喘、过敏和肺动脉高压。
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Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma.支气管反应性与细胞内镁:镁在哮喘中产生支气管扩张作用的一种可能机制。
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[Magnesium: therapeutic usefulness in emergency situations].[镁:在紧急情况下的治疗用途]
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Intravenous magnesium sulfate in acute, life-threatening asthma.静脉注射硫酸镁治疗急性、危及生命的哮喘。
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[Therapy with cardiac glycosides and electrolytes with particular consideration of fixed combinations (author's transl)].[洋地黄类强心苷与电解质治疗,特别考虑固定复方制剂(作者译)]
Arzneimittelforschung. 1977;27(3a):724-5.