Mathew R, Altura B M
New York Medical College, Valhalla.
Magnes Trace Elem. 1991;10(2-4):220-8.
Magnesium is the fourth most abundant metal found in the body. It plays a crucial role in numerous biological processes. It is a natural calcium blocker. It can block or compete with Ca2+ at voltage-dependent, receptor- or leak-operated channels and result in translocation of intracellular Ca2+. Mg2+ inhibits Ca2+ release from the sarcoplasmic reticulum. Intracellular Mg2+ is thought to modulate smooth muscle contractions and the rate of relaxation. Mg2+ is a cofactor of numerous enzymes and is coupled with cellular use of phosphate as an activator and energy source. cAMP-dependent protein and adenylate cyclase are among many enzymes that require Mg2+ for their function. Mg2+ has been used successfully in treating asthma. There is experimental evidence that Mg2+ is required for various immune responses, and in rats, Mg2+ treatment has been shown to attenuate chemically induced pulmonary hypertension. It is not clear if Mg2+ deficiency plays a role in development of some of these diseases, but Mg2+ salts appear to have therapeutic value and certainly it has a role as an adjunct to traditional therapy in various lung diseases.
镁是人体中含量第四丰富的金属。它在众多生物过程中起着至关重要的作用。它是一种天然的钙阻滞剂。它可以在电压依赖性、受体或泄漏操作通道处阻断或与Ca2+竞争，导致细胞内Ca2+的转运。Mg2+抑制肌浆网释放Ca2+。细胞内Mg2+被认为可调节平滑肌收缩和舒张速率。Mg2+是众多酶的辅助因子，并作为激活剂和能量来源与细胞对磷酸盐的利用相关联。环磷酸腺苷依赖性蛋白和腺苷酸环化酶是众多需要Mg2+发挥功能的酶中的一部分。Mg2+已成功用于治疗哮喘。有实验证据表明，各种免疫反应都需要Mg2+，并且在大鼠中，已证明Mg2+治疗可减轻化学诱导的肺动脉高压。目前尚不清楚Mg2+缺乏是否在其中一些疾病的发展中起作用，但Mg2+盐似乎具有治疗价值，并且在各种肺部疾病中，它肯定可作为传统疗法的辅助手段发挥作用。
