[评估儿茶酚胺及其主要代谢产物测定在嗜铬细胞瘤诊断中的应用价值]

[Evaluation of the usefulness for measuring catecholamines and their principle metabolites in the diagnosis of pheochromocytoma].

作者信息

Wocial B, Januszewicz W, Gryglas P, Januszewicz A, Feltynowski T, Lapiński M

机构信息

Katedry i Kliniki Chorób Wewnetrznych, Akademii Medycznej w Warszawie.

出版信息

Przegl Lek. 1997;54(11):793-8.

PMID:9501691

Abstract

Objective of the study was assessment of the usefulness of determination of noradrenaline (NA) and adrenaline (A) in urine and blood as well as the total methoxycatecholamines (MNA +MA), vanillylmandelic acid (VMA), DOPA and dopamine (DA) urinary excretion in diagnosis of pheochromocytoma. The experience based on 155 patients with pheochromocytoma (105F, 50M, age 18-82 yrs) diagnosed in the Department of Hypertension and Angiology Academy of Medicine in Warsaw will be discussed. In all patients excluding 2 cases pheochromocytoma has been proven histopathologically. The most considerable diagnostic usefulness of MNA + MA indication was proven. MNA + MA was increased in 96.6 patients. In 89.6% patients an increased excretion of NA and A or one of this catecholamines was demonstrated. An increased excretion of VMA was demonstrated in 75%. The excretion of DOPA and dopamine was tested in 120 cases. An increased excretion of DA was shown in 31% and DOPA in 16%.

摘要

本研究的目的是评估测定尿液和血液中的去甲肾上腺素（NA）、肾上腺素（A）以及总甲氧基儿茶酚胺（MNA + MA）、香草扁桃酸（VMA）、多巴（DOPA）和多巴胺（DA）的尿排泄量在嗜铬细胞瘤诊断中的作用。将讨论基于在华沙医学院高血压与血管病科诊断的155例嗜铬细胞瘤患者（105例女性，50例男性，年龄18 - 82岁）的经验。除2例患者外，所有患者的嗜铬细胞瘤均经组织病理学证实。已证实MNA + MA指标的诊断价值最为显著。96.6%的患者MNA + MA升高。89.6%的患者显示NA和A或其中一种儿茶酚胺的排泄增加。75%的患者显示VMA排泄增加。对120例患者进行了DOPA和多巴胺排泄量检测。31%的患者显示DA排泄增加，16%的患者显示DOPA排泄增加。