Wocial B, Januszewicz W, Gryglas P, Januszewicz A, Feltynowski T, Lapiński M
Katedry i Kliniki Chorób Wewnetrznych, Akademii Medycznej w Warszawie.
Przegl Lek. 1997;54(11):793-8.
Objective of the study was assessment of the usefulness of determination of noradrenaline (NA) and adrenaline (A) in urine and blood as well as the total methoxycatecholamines (MNA +MA), vanillylmandelic acid (VMA), DOPA and dopamine (DA) urinary excretion in diagnosis of pheochromocytoma. The experience based on 155 patients with pheochromocytoma (105F, 50M, age 18-82 yrs) diagnosed in the Department of Hypertension and Angiology Academy of Medicine in Warsaw will be discussed. In all patients excluding 2 cases pheochromocytoma has been proven histopathologically. The most considerable diagnostic usefulness of MNA + MA indication was proven. MNA + MA was increased in 96.6 patients. In 89.6% patients an increased excretion of NA and A or one of this catecholamines was demonstrated. An increased excretion of VMA was demonstrated in 75%. The excretion of DOPA and dopamine was tested in 120 cases. An increased excretion of DA was shown in 31% and DOPA in 16%.
本研究的目的是评估测定尿液和血液中的去甲肾上腺素（NA）、肾上腺素（A）以及总甲氧基儿茶酚胺（MNA + MA）、香草扁桃酸（VMA）、多巴（DOPA）和多巴胺（DA）的尿排泄量在嗜铬细胞瘤诊断中的作用。将讨论基于在华沙医学院高血压与血管病科诊断的155例嗜铬细胞瘤患者（105例女性，50例男性，年龄18 - 82岁）的经验。除2例患者外，所有患者的嗜铬细胞瘤均经组织病理学证实。已证实MNA + MA指标的诊断价值最为显著。96.6%的患者MNA + MA升高。89.6%的患者显示NA和A或其中一种儿茶酚胺的排泄增加。75%的患者显示VMA排泄增加。对120例患者进行了DOPA和多巴胺排泄量检测。31%的患者显示DA排泄增加，16%的患者显示DOPA排泄增加。
