剪接：入侵未折叠蛋白反应
Splicing: HACking into the unfolded-protein response.
作者信息
Shamu C E
机构信息
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Curr Biol. 1998 Feb 12;8(4):R121-3. doi: 10.1016/s0960-9822(98)70986-8.
PMID:9501974
Abstract
Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase.
摘要
酿酒酵母内质网中的未折叠蛋白会引发一种特殊的RNA剪接事件，该事件能使转录因子Hac1p随后进行翻译。这种剪接可以用Ire1p（一种具有位点特异性核糖核酸酶活性的跨膜激酶）和tRNA连接酶来重建。
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