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拼接未折叠蛋白反应。

Splicing together the unfolded-protein response.

作者信息

Shamu C E

机构信息

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Curr Biol. 1997 Feb 1;7(2):R67-70. doi: 10.1016/s0960-9822(06)00038-8.

DOI:10.1016/s0960-9822(06)00038-8
PMID:9081665
Abstract

Recent work has identified a transcription factor, Hac1p, in the yeast Saccharomyces cerevisiae, as a component of a pathway that signals to the nucleus the presence of unfolded proteins in the endoplasmic reticulum and has shown that Hac1p expression is regulated by a novel RNA splicing pathway.

摘要

最近的研究工作已在酿酒酵母中鉴定出一种转录因子Hac1p，它是一种向细胞核传递内质网中未折叠蛋白存在信号的通路的组成部分，并且表明Hac1p的表达受一种新型RNA剪接通路调控。

相似文献

1
Splicing together the unfolded-protein response.拼接未折叠蛋白反应。
Curr Biol. 1997 Feb 1;7(2):R67-70. doi: 10.1016/s0960-9822(06)00038-8.
2
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.一种调控控制未折叠蛋白反应的转录因子活性的新机制。
Cell. 1996 Nov 1;87(3):391-404. doi: 10.1016/s0092-8674(00)81360-4.
3
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response.内质网应激诱导的mRNA剪接允许转录因子Hac1p/Ern4p的合成，该转录因子激活未折叠蛋白反应。
Mol Biol Cell. 1997 Oct;8(10):1845-62. doi: 10.1091/mbc.8.10.1845.
4
Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway.从内质网到细胞核的信号传导：未折叠蛋白反应途径需要具有碱性亮氨酸拉链基序的转录因子。
Genes Cells. 1996 Sep;1(9):803-17. doi: 10.1046/j.1365-2443.1996.d01-274.x.
5
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response.tRNA连接酶是未折叠蛋白反应中调控mRNA剪接所必需的。
Cell. 1996 Nov 1;87(3):405-13. doi: 10.1016/s0092-8674(00)81361-6.
6
mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response.高效激活未折叠蛋白反应需要mRNA剪接介导的转录因子Hac1p的C端替换。
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4660-5. doi: 10.1073/pnas.050010197.
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Splicing: HACking into the unfolded-protein response.剪接：入侵未折叠蛋白反应
Curr Biol. 1998 Feb 12;8(4):R121-3. doi: 10.1016/s0960-9822(98)70986-8.
8
IRE1-independent gain control of the unfolded protein response.未折叠蛋白反应的IRE1非依赖性增益控制
PLoS Biol. 2004 Aug;2(8):E235. doi: 10.1371/journal.pbio.0020235. Epub 2004 Aug 17.
9
A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum.未折叠蛋白反应与内质网囊泡形成之间的遗传联系。
Biochem Biophys Res Commun. 2002 Aug 23;296(3):568-74. doi: 10.1016/s0006-291x(02)00923-3.
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IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast.酵母未折叠蛋白反应中不依赖于IRE1和HAC1的转录调控
Mol Microbiol. 2003 Aug;49(3):591-606. doi: 10.1046/j.1365-2958.2003.03585.x.

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Effects of inactivation and constitutive expression of the unfolded- protein response pathway on protein production in the yeast Saccharomyces cerevisiae.未折叠蛋白反应途径的失活和组成型表达对酿酒酵母中蛋白质生产的影响。
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