唐氏综合征患者血浆β淀粉样蛋白1-42水平升高。

Increased plasma amyloid beta protein 1-42 levels in Down syndrome.

作者信息

Mehta P D, Dalton A J, Mehta S P, Kim K S, Sersen E A, Wisniewski H M

机构信息

Department of Immunology, New York State Institute for Basic Research, Staten Island 10314-6399, USA.

出版信息

Neurosci Lett. 1998 Jan 23;241(1):13-6. doi: 10.1016/s0304-3940(97)00966-x.

DOI:10.1016/s0304-3940(97)00966-x

PMID:9502204

Abstract

Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.

摘要

采用夹心酶联免疫吸附测定法，对43名唐氏综合征患者（DS；26 - 68岁）、43名年龄匹配的正常对照者以及19名非DS智力发育迟缓（MR）者（26 - 91岁）血浆中的β淀粉样蛋白1 - 40（Aβ40）和Aβ42水平进行了定量分析。DS组和MR组的Aβ40水平高于对照组，但DS组和MR组之间相似。DS组的Aβ42水平高于对照组或MR者。DS组的Aβ42/Aβ40比值高于对照组或MR者。这些发现与在唐氏综合征患者大脑中观察到的结果一致。