蛋白质聚集：折叠聚集体、包涵体与淀粉样蛋白。
Protein aggregation: folding aggregates, inclusion bodies and amyloid.
作者信息
Fink A L
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA.
出版信息
Fold Des. 1998;3(1):R9-23. doi: 10.1016/S1359-0278(98)00002-9.
PMID:9502314
Abstract
Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.
摘要
聚集会导致包涵体、淀粉样纤维和折叠聚集体的形成。大量数据支持这样的假说：部分折叠的中间体是聚集体的关键前体，聚集涉及特定的分子间相互作用，并且大多数聚集体都包含β折叠片层。
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