Carey D G
Institute of Clinical Nutrition and Metabolism in the Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia.
Curr Opin Lipidol. 1998 Feb;9(1):35-40. doi: 10.1097/00041433-199802000-00008.
The application of magnetic resonance imaging and computed tomography to obesity research has changed the focus from body mass and skinfold thickness to abdominal fat mass and visceral adiposity. Intra-abdominal fat constitutes less than 20% of total body fat but is a major determinant of fasting and postprandial lipid availability because of its physiological (lipolytic rate and insulin resistance) and anatomical (portal drainage) properties. High levels of serum free fatty acids, as a result of abdominal obesity, cause excessive tissue lipid accumulation and contribute to dyslipidaemia, beta cell dysfunction, and hepatic and peripheral insulin resistance. An individual's risk of non-insulin dependent diabetes mellitus and cardiovascular disease relates closely to the inheritance of central obesity and susceptibility to tissue lipotoxicity.
磁共振成像和计算机断层扫描在肥胖研究中的应用，已将关注点从体重和皮褶厚度转移至腹部脂肪量和内脏肥胖。腹部脂肪占全身脂肪的比例不到20%，但由于其生理特性（脂肪分解率和胰岛素抵抗）和解剖学特性（门静脉引流），它是空腹和餐后脂质供应的主要决定因素。腹部肥胖导致的高水平血清游离脂肪酸会引起组织脂质过度蓄积，并导致血脂异常、β细胞功能障碍以及肝脏和外周胰岛素抵抗。个体患非胰岛素依赖型糖尿病和心血管疾病的风险与中心性肥胖的遗传因素以及对组织脂毒性的易感性密切相关。
