Ohlsson A, Nordlander R, Bennett T, Bitkover C, Kjellström B, Lee B, Rydén L
Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
Eur Heart J. 1998 Jan;19(1):174-84. doi: 10.1053/euhj.1997.0563.
This study evaluates the feasibility and safety of a completely implantable system for long-term ambulatory monitoring of important haemodynamic parameters in patients with severe cardiopulmonary disease.
The design of the implantable monitoring system is similar to a conventional single lead pacemaker. A lead with incorporated biosensors for the continuous recording of pressure and oxygen saturation signals is positioned in the right ventricle and connected to a monitor and memory device subcutaneously implanted like an ordinary pacemaker can.
Five patients with implanted haemodynamic monitoring systems have been followed for from 7 to 16 months. Continuous measurements of activity, heart rate, mixed venous oxygen saturation and estimated pulmonary artery diastolic pressure were registered with variable resolution during daily living and predefined provocations. The memory covered a maximum of 3 weeks at low resolution. The monitored parameters showed an adequate and significant response to various haemodynamic situations. Except for the demand of recalibration of two oxygen sensors, there were no technical problems and the quality of data were excellent.
Long-term ambulatory haemodynamic monitoring is feasible and potentially useful for the management of patients with severe cardiopulmonary disease.
本研究评估一种完全可植入系统用于严重心肺疾病患者长期动态监测重要血流动力学参数的可行性和安全性。
可植入监测系统的设计类似于传统单腔起搏器。一根带有用于连续记录压力和血氧饱和度信号的生物传感器的导线置于右心室，并连接到一个像普通起搏器一样皮下植入的监测器和存储装置。
5例植入血流动力学监测系统的患者已随访7至16个月。在日常生活和预设激发试验期间，以可变分辨率连续记录活动、心率、混合静脉血氧饱和度和估计肺动脉舒张压。存储器以低分辨率最多可存储3周。监测参数对各种血流动力学情况显示出充分且显著的反应。除了需要重新校准两个氧传感器外，没有技术问题，数据质量极佳。
长期动态血流动力学监测对于严重心肺疾病患者的管理是可行的且可能有用。
