Ohlsson A, Beck R, Bennett T, Nordlander R, Rydén J, Aström H, Rydén L
Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
Eur Heart J. 1995 Sep;16(9):1215-22. doi: 10.1093/oxfordjournals.eurheartj.a061078.
Right ventricle venous oxygen saturation was studied in 10 heart failure patients over 24 h using a lead equipped with an oxygen biosensor inserted temporarily. At the same time a pressure sensor, incorporated in the same lead to measure right ventricular pulse pressure and maximum positive and negative rate of pressure development (RV dP/dt), was tested to see whether it would interfere with the oxygen sensor. Data from the biosensor lead were continuously compared with mixed venous oxygen saturation obtained from a fibreoptic Swan-Ganz catheter with the tip in the pulmonary artery. For reference, blood samples were drawn at regular intervals from this catheter. A provocative protocol was used to cause haemodynamic changes. There was good correlation between oxygen saturation in the right ventricle (biosensor-derived) and mixed venous oxygen saturation in the pulmonary artery (fibreoptic-derived) (r = 0.86) and between sensor-obtained right ventricular oxygen saturation and oxygen saturation in the blood samples from the pulmonary artery (r = 0.90). Changes in central haemodynamics were also well reflected by changes in pulse pressure and dP/dt derived from the pressure sensor. As it was not possible to obtain absolute pressures no attempt was made to compare the pressure changes with conventional haemodynamics. These 24 h haemodynamic measurements suggest that a biosensor-equipped lead placed in the right ventricle could be a valuable tool for long-term monitoring of mixed venous oxygen saturation and pressure in patients with congestive heart failure.
对10例心力衰竭患者使用临时插入的配备氧生物传感器的导联进行了24小时右心室静脉血氧饱和度研究。同时，对同一导联中用于测量右心室脉压以及压力上升和下降最大正负速率（右心室dP/dt）的压力传感器进行测试，以观察其是否会干扰氧传感器。将生物传感器导联的数据与通过位于肺动脉内尖端的光纤Swan-Ganz导管获得的混合静脉血氧饱和度持续进行比较。作为对照，定期从该导管采集血样。采用激发方案引起血流动力学变化。右心室（源自生物传感器）血氧饱和度与肺动脉（源自光纤）混合静脉血氧饱和度之间存在良好相关性（r = 0.86），传感器获得的右心室血氧饱和度与肺动脉血样中的血氧饱和度之间也存在良好相关性（r = 0.90）。中心血流动力学的变化也能很好地通过压力传感器得出的脉压和dP/dt的变化反映出来。由于无法获得绝对压力，因此未尝试将压力变化与传统血流动力学进行比较。这些24小时血流动力学测量结果表明，置于右心室的配备生物传感器的导联可能是长期监测充血性心力衰竭患者混合静脉血氧饱和度和压力的有价值工具。
