• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycineB and AMPA antagonists. Short communication.

作者信息

Lazarewicz J W, Gadamski R, Parsons C G, Danysz W

机构信息

Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

出版信息

J Neural Transm (Vienna). 1997;104(11-12):1249-54. doi: 10.1007/BF01294724.

DOI:10.1007/BF01294724
PMID:9503269
Abstract

Novel antagonists of the glycineB site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neurones in the CA1 region, which was prevented by NBQX, and reduced to 50% by both glycineB antagonists. NBQX produced a delayed, long lasting (up to 24 hr) hypothermia while hypothermia with both glycineB antagonists was transient.

摘要

相似文献

1
Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycineB and AMPA antagonists. Short communication.
J Neural Transm (Vienna). 1997;104(11-12):1249-54. doi: 10.1007/BF01294724.
2
Effects of the AMPA-receptor antagonist, NBQX, on neuron loss in dentate hilus of the hippocampal formation after 8, 10, or 12 min of cerebral ischemia in the rat.AMPA受体拮抗剂NBQX对大鼠脑缺血8、10或12分钟后海马结构齿状回神经元丢失的影响。
J Cereb Blood Flow Metab. 1997 Feb;17(2):147-52. doi: 10.1097/00004647-199702000-00003.
3
Neuroprotective effect of YM90K, an AMPA-receptor antagonist, against delayed neuronal death induced by transient global cerebral ischemia in gerbils and rats.
Jpn J Pharmacol. 1997 Jul;74(3):253-60. doi: 10.1254/jjp.74.253.
4
NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus.N-甲基-D-天冬氨酸（NMDA）受体拮抗作用而非α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体拮抗作用可减轻沙鼠海马体中的诱导性缺血耐受。
Eur J Pharmacol. 1999 Sep 10;380(2-3):91-9. doi: 10.1016/s0014-2999(99)00523-3.
5
The neuroprotective and hypothermic effect of GYKI-52466, a non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-antagonist on histological and behavioural variables in the gerbil global ischemia model.非竞争性α-氨基-3-羟基-5-甲基-4-异恶唑丙酸拮抗剂GYKI-52466对沙鼠全脑缺血模型组织学和行为学变量的神经保护及低温作用。
Brain Res Bull. 1999 Oct;50(3):179-86. doi: 10.1016/s0361-9230(99)00186-0.
6
Protection against post-ischemic behavioral pathology by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil.α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）拮抗剂2,3-二羟基-6-硝基-7-氨磺酰基苯并[f]喹喔啉（NBQX）对沙鼠缺血后行为病理学的保护作用
Neurosci Lett. 1991 Dec 9;133(2):291-4. doi: 10.1016/0304-3940(91)90591-g.
7
Protection against ischemic hippocampal CA1 damage in the rat with a new non-NMDA antagonist, NBQX.新型非NMDA拮抗剂NBQX对大鼠缺血性海马CA1损伤的保护作用
Acta Neurol Scand. 1992 Jul;86(1):45-9. doi: 10.1111/j.1600-0404.1992.tb08052.x.
8
Neuroprotective effects of the AMPA antagonist PNQX in oxygen-glucose deprivation in mouse hippocampal slice cultures and global cerebral ischemia in gerbils.AMPA拮抗剂PNQX对小鼠海马脑片培养物氧糖剥夺及沙土鼠全脑缺血的神经保护作用。
Brain Res. 2007 Oct 26;1177:124-35. doi: 10.1016/j.brainres.2007.08.038. Epub 2007 Aug 24.
9
Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia.N-甲基-D-天冬氨酸受体甘氨酸位点拮抗剂在全脑缺血中的评估
Brain Res. 1999 Feb 20;819(1-2):65-74. doi: 10.1016/s0006-8993(98)01329-8.
10
NMDA and AMPA/kainate glutamate receptors modulate dentate neurogenesis and CA3 synapsin-I in normal and ischemic hippocampus.N-甲基-D-天冬氨酸（NMDA）和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸/海人藻酸（AMPA/kainate）谷氨酸受体调节正常和缺血海马体中的齿状回神经发生及CA3区突触素-I。
J Cereb Blood Flow Metab. 2000 Dec;20(12):1669-80. doi: 10.1097/00004647-200012000-00006.

引用本文的文献

1
Glutamate receptors in neuroinflammatory demyelinating disease.神经炎性脱髓鞘疾病中的谷氨酸受体
Mediators Inflamm. 2006;2006(2):93684. doi: 10.1155/MI/2006/93684.
2
NMDA receptor antagonism does not inhibit induction of ischemic tolerance in gerbil brain in vivo.N-甲基-D-天冬氨酸（NMDA）受体拮抗作用并不抑制沙土鼠脑体内缺血耐受性的诱导。
Neurotox Res. 2005;7(4):283-92. doi: 10.1007/BF03033886.
3
Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders.AMPA/红藻氨酸受体配体的药理学及其在神经和精神疾病中的治疗潜力。

本文引用的文献

1
Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization.新型N-甲基-D-天冬氨酸受体甘氨酸位点的全身活性拮抗剂：电生理、生化及行为学特性研究
J Pharmacol Exp Ther. 1997 Dec;283(3):1264-75.
2
Neuroprotection after several days of mild, drug-induced hypothermia.数天轻度药物诱导性低温后的神经保护作用。
J Cereb Blood Flow Metab. 1996 May;16(3):474-80. doi: 10.1097/00004647-199605000-00014.
3
The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil.
Drugs. 2000 Jan;59(1):33-78. doi: 10.2165/00003495-200059010-00004.
甘氨酸拮抗剂和自由基清除剂7-氯硫代犬尿氨酸可减轻沙鼠CA1区的缺血性损伤。
Neuroscience. 1994 Dec;63(3):701-9. doi: 10.1016/0306-4522(94)90516-9.
4
Effects of MK-801 and ganglioside GM1 on postischemic prostanoid release and hippocampal lesion in gerbil brain.MK-801和神经节苷脂GM1对沙土鼠脑缺血后前列腺素释放及海马损伤的影响。
Acta Neurobiol Exp (Wars). 1994;54(4):293-305.
5
The effect of an AMPA antagonist (NBQX) on postischemic neuron loss and protein synthesis in the rat brain.一种AMPA拮抗剂（NBQX）对大鼠脑缺血后神经元丢失及蛋白质合成的影响。
Exp Brain Res. 1993;95(1):70-6. doi: 10.1007/BF00229655.
6
Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury.脑缺血期间脑温的微小差异严重决定了缺血性神经元损伤的程度。
J Cereb Blood Flow Metab. 1987 Dec;7(6):729-38. doi: 10.1038/jcbfm.1987.127.
7
MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period.在沙土鼠缺血后阶段给药时，MK-801具有神经保护作用。
Neuroscience. 1988 Jun;25(3):847-55. doi: 10.1016/0306-4522(88)90040-1.
8
The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat.谷氨酸拮抗剂MK-801可减轻大鼠局灶性缺血性脑损伤。
Ann Neurol. 1988 Oct;24(4):543-51. doi: 10.1002/ana.410240411.
9
Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia.体温过低而非N-甲基-D-天冬氨酸拮抗剂MK-801可减轻沙土鼠短暂性全脑缺血后的神经元损伤。
J Neurosci. 1990 Jan;10(1):311-6. doi: 10.1523/JNEUROSCI.10-01-00311.1990.
10
Effects of normothermic versus mild hyperthermic forebrain ischemia in rats.大鼠正常体温与轻度高温性前脑缺血的影响。
Stroke. 1990 Sep;21(9):1318-25. doi: 10.1161/01.str.21.9.1318.