Isa T, Kusano T, Muto Y, Furukawa M, Kiyuna M, Toda T
First Department of Surgery, Ryukyu University School of Medicine, Okinawa, Japan.
J Clin Gastroenterol. 1997 Dec;25(4):623-7. doi: 10.1097/00004836-199712000-00015.
Four cases of resected adenosquamous carcinoma of the liver were clinicopathologically reviewed, together with immunohistochemical findings. Although no lymph node metastases were seen and a curative resection was achieved in all cases, two patients had recurrences in the peritoneum and distant organs such as the pericardium and pleura relatively soon after the operation. Of the remaining two cases, one patient died during the postoperative period and the other died of coexistent hilar cholangiocarcinoma. Together these findings suggest that this disease tends to spread locally and distantly in the early phase of tumor growth and shows aggressive biological behavior. In an immunohistochemical study, involucrin was a specific marker for the squamous component and CA19-9 was a marker for the adenomatous component.
对4例手术切除的肝腺鳞癌进行了临床病理检查及免疫组化分析。尽管所有病例均未见淋巴结转移且均实现了根治性切除，但2例患者在术后不久即在腹膜及远处器官如心包和胸膜出现复发。其余2例中，1例患者在术后期间死亡，另1例死于并存的肝门胆管癌。这些结果共同表明，该疾病在肿瘤生长早期易于局部和远处扩散，并表现出侵袭性生物学行为。在免疫组化研究中，兜甲蛋白是鳞状成分的特异性标志物，而CA19-9是腺瘤成分的标志物。
