Morales-Polanco M R, Guerrero-Rivera S, Sánchez-Valle E, Gómez-Morales E, Gordon-Barabejzyk F, Mejía-Arregui M, Rosales-Orozco O
Servicio de Hematología, Hospital de Especialidades Bernardo Sepúlveda, México, D.F.
Gac Med Mex. 1997 Sep-Oct;133(5):399-402.
Erythropoietin (EPO) is the hematopoietic growth factor that regulates red cell production. There is a direct relationship between its secretion and tissue hypoxia. Above sea level, oxygen concentration diminishes. This causes an increase of hemoglobin and hematocrit; this effect could be the consequence of higher EPO levels. Currently, evaluation of baseline serum EPO levels is very important in the differential diagnosis of anemia and erythrocytosis. The purpose of the present work was to report the EPO levels on a group of healthy blood donors living in Mexico City, 2,240 m above sea level. Two-hundred twenty blood donors were selected to measure serum EPO; there were 168 males and 52 females. Median EPO levels of the entire population were 7.5 mU/mL (percentile interval, PI, 1-18). Median EPO levels were 7.6 (PI 1-18) and 7.5 (PI 1-16.9) for men and women, respectively. We did not find differences in serum EPO levels among previous reports in other populations and the values determined in this study.
促红细胞生成素（EPO）是调节红细胞生成的造血生长因子。其分泌与组织缺氧之间存在直接关系。在海平面以上，氧气浓度降低。这会导致血红蛋白和血细胞比容增加；这种效应可能是EPO水平升高的结果。目前，评估基线血清EPO水平在贫血和红细胞增多症的鉴别诊断中非常重要。本研究的目的是报告一组居住在海拔2240米的墨西哥城的健康献血者的EPO水平。选择220名献血者测量血清EPO；其中男性168名，女性52名。整个人群的EPO水平中位数为7.5 mU/mL（百分位数区间，PI，1 - 18）。男性和女性的EPO水平中位数分别为7.6（PI 1 - 18）和7.5（PI 1 - 16.9）。我们未发现本研究确定的值与其他人群先前报告的血清EPO水平存在差异。
