Norlander T, Kwon S H, Henriksson G, Westrin K M, Sandstedt K, Stierna P
Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Sweden.
Laryngoscope. 1998 Mar;108(3):411-7. doi: 10.1097/00005537-199803000-00018.
To investigate possible effects of corticosteroids on polyp formation and local bacterial colonization, pneumococcal sinusitis was experimentally induced in rabbits pretreated with betamethasone or saline. After 7 days, macroscopic polyps were counted post-mortem and on histologic slides after serial sectioning. Histologic sections were also examined with light microscopy. Macroscopic polyps were significantly fewer in animals given betamethasone, while there was no difference regarding the number of microscopic polyps. Ingrowth of pathogenic microorganisms was found in five of eight rabbits given placebo but in none of the animals treated with corticosteroids (P < 0.05). The reduced number of pathogenic strains in these animals may be explained by a better-preserved local host defense. The lower number of macroscopic polyps in the same animals could be because of a delayed mucosal repair and subsequent polyp formation.
为研究皮质类固醇对息肉形成和局部细菌定植的可能影响，对用倍他米松或生理盐水预处理的家兔进行实验性肺炎球菌性鼻窦炎诱导。7天后，在死后对肉眼可见的息肉进行计数，并在连续切片后的组织学载玻片上进行计数。组织学切片也用光学显微镜检查。给予倍他米松的动物中肉眼可见的息肉明显较少，而显微镜下息肉的数量没有差异。给予安慰剂的8只家兔中有5只发现有致病微生物生长，而接受皮质类固醇治疗的动物中均未发现（P<0.05）。这些动物中致病菌株数量的减少可能是由于局部宿主防御得到更好的保存。同一批动物中肉眼可见息肉数量较少可能是由于黏膜修复延迟和随后的息肉形成。
