两例伴有噬红细胞现象的急性髓系白血病患者的inv(8)(p11q13)：一种新的细胞遗传学变异型
Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant.
作者信息
Coulthard S, Chase A, Orchard K, Watmore A, Vora A, Goldman J M, Swirsky D M
机构信息
Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London.
出版信息
Br J Haematol. 1998 Mar;100(3):561-3. doi: 10.1046/j.1365-2141.1998.00587.x.
We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.
我们描述了两名患有急性髓系白血病（AML）并伴有噬红细胞现象及8号染色体臂间倒位inv(8)(p11q13)的患者。血液学特征与t(8;16)综合征及其变异型患者的特征无法区分。我们的观察结果强调了8p11断点的重要性以及MOZ基因在所有这些病例中可能的参与情况。
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