意大利一个家系中强迫症和病态赌博与亨廷顿病的关联：可能与亨廷顿病突变有关

Association of obsessive-compulsive disorder and pathological gambling with Huntington's disease in an Italian pedigree: possible association with Huntington's disease mutation.

作者信息

De Marchi N, Morris M, Mennella R, La Pia S, Nestadt G

机构信息

Department of Psychiatry, University of Naples, Italy.

出版信息

Acta Psychiatr Scand. 1998 Jan;97(1):62-5. doi: 10.1111/j.1600-0447.1998.tb09964.x.

DOI:10.1111/j.1600-0447.1998.tb09964.x

PMID:9504705

Abstract

This paper describes a pedigree with Huntington's disease (HD), in which three cases of obsessive-compulsive disorder (OCD) and two cases of pathological gambling (PG) were identified. The mutation analysis of the HD gene was carried out in the examined individuals who were at risk for HD. In fact, OCD and PG only occurred in carriers of the HD expansion. The possible implications of this finding are discussed.

摘要

本文描述了一个患有亨廷顿舞蹈症（HD）的家系，其中发现了3例强迫症（OCD）和2例病态赌博（PG）病例。对有HD风险的受检个体进行了HD基因的突变分析。事实上，OCD和PG仅发生在HD扩展突变的携带者中。本文讨论了这一发现可能的意义。