De Marchi N, Morris M, Mennella R, La Pia S, Nestadt G
Department of Psychiatry, University of Naples, Italy.
Acta Psychiatr Scand. 1998 Jan;97(1):62-5. doi: 10.1111/j.1600-0447.1998.tb09964.x.
This paper describes a pedigree with Huntington's disease (HD), in which three cases of obsessive-compulsive disorder (OCD) and two cases of pathological gambling (PG) were identified. The mutation analysis of the HD gene was carried out in the examined individuals who were at risk for HD. In fact, OCD and PG only occurred in carriers of the HD expansion. The possible implications of this finding are discussed.
本文描述了一个患有亨廷顿舞蹈症（HD）的家系，其中发现了3例强迫症（OCD）和2例病态赌博（PG）病例。对有HD风险的受检个体进行了HD基因的突变分析。事实上，OCD和PG仅发生在HD扩展突变的携带者中。本文讨论了这一发现可能的意义。
