Phocas I, Sarandakou A, Giannaki G, Malamitsi-Puchner A, Rizos D, Zourlas P A
Second Department of Obstetrics and Gynaecology, Areteion University Hospital, Athens, Greece.
Eur J Pediatr. 1998 Feb;157(2):153-6. doi: 10.1007/s004310050788.
The aim of this study was to evaluate the effect of increasing postnatal age on soluble intercellular adhesion molecule-1 (sICAM-1), a very early and sensitive marker of immune activation and response in the serum of newborn infants. Serum sICAM-1 was measured by EIA (T Cell Diagnostics) in 20 healthy adults (controls) and in 43 (24 females/19 males) healthy neonates, of whom 28 were full term, and 15 were born at a gestational age between 35 and 38 weeks of pregnancy, on the 1st, 5th and 30th day of life. Neonatal serum sICAM-1 values showed a very significant increase (P < 0.01) from the 1st day (137.3+/-62.0 ng/ml) to the 5th day (259.3+/-124.0 ng/ml) and then to the 30th day of life (415.0+/-114.0 ng/ml), being significantly lower on the 1st day (P < 0.01), whereas significantly higher on the 30th day of life (P < 0.05), than those in healthy adults (305+/-195 ng/ml). Serum sICAM-1 values on the 1st day of life depended on both the mode of delivery (significantly higher in neonates born vaginally) and the gestational age at birth (significantly lower in those born at a gestational age over 38 weeks). A significant strong correlation was found in sICAM-1 values between the 1st and the 5th day following delivery (rp = 0.77, P < 0.009).
The results of this study demonstrate a significant rise of serum sICAM-1 during the 1st month of life in healthy neonates suggesting a progressively increased activation of the neonatal immune system.
本研究的目的是评估出生后年龄增加对可溶性细胞间黏附分子-1（sICAM-1）的影响，sICAM-1是新生儿血清中免疫激活和反应的一种非常早期且敏感的标志物。采用酶免疫分析法（T细胞诊断）对20名健康成年人（对照组）和43名（24名女性/19名男性）健康新生儿的血清sICAM-1进行检测，其中28名足月儿，15名出生时孕周在35至38周之间，分别在出生后第1天、第5天和第30天进行检测。新生儿血清sICAM-1值从出生第1天（137.3±62.0 ng/ml）到第5天（259.3±124.0 ng/ml）再到出生后第30天（415.0±114.0 ng/ml）呈现非常显著的升高（P<0.01），出生第1天显著低于第30天（P<0.05），且出生第1天显著低于健康成年人（305±195 ng/ml）（P<0.01），而出生后第30天显著高于健康成年人（P<0.05）。出生第1天的血清sICAM-1值既取决于分娩方式（经阴道分娩的新生儿显著更高），也取决于出生时的孕周（孕周超过38周的新生儿显著更低）。在出生后第1天和第5天之间的sICAM-1值存在显著的强相关性（rp = 0.77，P<0.009）。
本研究结果表明，健康新生儿在出生后第1个月内血清sICAM-1显著升高，提示新生儿免疫系统的激活逐渐增加。
