Zuber M, Kranzhöfer N, Lindemuth R, Hartmann F
Medizinische Klinik I, Universitätkliniken des Saarlandes.
Med Klin (Munich). 1998 Jan 15;93(1):34-8. doi: 10.1007/BF03045038.
A 32-year-old female patient is described who suffered from common symptoms such as Raynaud's phenomenon and swollen fingers, high titers of antibodies to U1RNP, SLE-like findings, scleroderma-like findings and polymyositis-like findings. A diagnosis of mixed connective tissue disease (Sharp-syndrome) was established. In addition, the patient had antibodies against cardiolipin, thrombocytopenia, recurrent fetal loss and a history of deep venous thrombosis of her left leg which is typical for an antiphospholipid syndrome. The symptoms dry eyes and dry mouth pointed at secondary Sjögren's syndrome. The diagnosis of these disease entities and the therapeutic regimens are described and discussed.
本文描述了一名32岁女性患者，她有雷诺现象、手指肿胀等常见症状，抗U1RNP抗体滴度高，有系统性红斑狼疮样表现、硬皮病样表现和多发性肌炎样表现。确诊为混合性结缔组织病（夏普综合征）。此外，该患者有抗心磷脂抗体、血小板减少、反复流产史以及左腿深静脉血栓形成史，这是抗磷脂综合征的典型表现。干眼和口干症状提示继发性干燥综合征。文中描述并讨论了这些疾病实体的诊断及治疗方案。
