Finol H J, Correa M, Márquez A, Tonino P, Sosa L A
Center for Electron Microscopy, Sciences Faculty, Venezuela Central University, Caracas, Venezuela.
J Exp Clin Cancer Res. 1997 Dec;16(4):381-4.
The electron microscopic examination of biopsies from liver metastases of a colon leiomyosarcoma showed the existence of alterations not previously reported in primary tumors of that kind. Those abnormalities included proliferation of lysosomal structures as multivesicular bodies, myelin-like figures, lipofuscin granules and autophagic vacuoles, along with mitochondrial changes as concentric and vesiculated cristae, and presence of dense granules and elongated inclusions. This study suggests that, in this tumor and host tissue, the so-called invasive phenotype, which is supposed to form the metastases, could have a distinct morphological picture at the ultrastructural level.
对一例结肠平滑肌肉瘤肝转移灶活检组织进行的电子显微镜检查显示，存在一些此前在该类原发性肿瘤中未报告过的改变。这些异常包括溶酶体结构的增殖，如多泡体、髓鞘样结构、脂褐素颗粒和自噬空泡，以及线粒体改变，如同心状和泡状嵴，还有致密颗粒和细长内含物的存在。本研究表明，在这种肿瘤和宿主组织中，据推测形成转移灶的所谓侵袭性表型在超微结构水平可能具有独特的形态学特征。
