Cameselle-Teijeiro J, Alfonsín-Barreiro N, Allegue F, Caeiro M
Department of Pathology, Hospital Xeral de Galicia, Santiago, Spain.
Pathol Res Pract. 1997;193(10):713-20; discussion 721-22. doi: 10.1016/s0344-0338(97)80031-3.
A case of carcinoma of the axillary apocrine gland in a 42-year-old man is reported. The cytomorphic features of this tumor on fine-needle aspiration closely resemble invasive lobular carcinoma of the breast. Both in situ, and invasive apocrine gland carcinoma were present within the excision specimen, and metastatic tumor was found in the axillary lymph nodes. On histologic, immunohistochemical and ultrastructural examination, the tumor was similar to invasive lobular carcinoma of the breast. The tumor cells analyzed by cytometry displayed a diploid pattern. Serial sections of the whole resected specimen failed to reveal breast parenchyma. To the best of our knowledge, this is the first case presented in axilla of an unusual variant of carcinoma of the skin, very similar or identical to six other cases located on the eyelids. The descriptive term "apocrine carcinoma with signet ring cells and histiocytoid features" is proposed in order to emphasize that these tumors are easily confused with benign conditions, mammary cancer and other metastatic carcinomas.
报告了一例42岁男性腋窝大汗腺癌病例。该肿瘤细针穿刺的细胞形态特征与乳腺浸润性小叶癌极为相似。切除标本中同时存在原位和浸润性大汗腺癌，且在腋窝淋巴结中发现了转移瘤。经组织学、免疫组化和超微结构检查，该肿瘤与乳腺浸润性小叶癌相似。通过细胞计数分析的肿瘤细胞显示为二倍体模式。整个切除标本的连续切片未发现乳腺实质。据我们所知，这是首例出现在腋窝的一种不寻常的皮肤癌变体病例，与其他6例位于眼睑的病例非常相似或相同。为强调这些肿瘤容易与良性病变、乳腺癌及其他转移癌相混淆，建议使用描述性术语“伴有印戒细胞和组织细胞样特征的大汗腺癌”。
