Berdugo Jérémie, Dumont-Mackay Vincent, Brissy-Lachery Sophie, Leclerc Yves E, Doyon Josée, Mitchell Andrew, Petrella Tony, Désy Delphine
*Departments of Anatomic Pathology and Cytology, University of Montréal, Montréal, Québec, Canada;Departments of †Dermatology,‡Surgery, and§Anatomic Pathology and Cytology, Maisonneuve-Rosemont Hospital, Montréal, Québec, Canada.
Am J Dermatopathol. 2017 Jun;39(6):e76-e78. doi: 10.1097/DAD.0000000000000810.
We present a case of cutaneous apocrine carcinoma arising in the axilla of a 71-year-old man. The tumor had a significant component of histiocytoid and signet-ring cells as well as in situ carcinoma within the apocrine glands. The cells expressed GATA3, gross cystic disease fluid protein 15, androgen receptor, and E-cadherin. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 were negative. Clinical correlation was required to rule out a metastasis from the breast or the gastrointestinal tract. Although most cutaneous apocrine carcinomas do not behave aggressively, our patient developed bone metastases and eventually died of his disease. It is debated whether histiocytoid and signet-ring cell cutaneous carcinomas should be classified as apocrine neoplasm. The presence of in situ carcinoma associated with this kind of tumor has been reported only once in the literature. This characteristic and the immunohistochemical profile are in favor of apocrine differentiation.
我们报告一例发生于一名71岁男性腋窝的皮肤大汗腺癌。肿瘤有显著的组织细胞样和印戒细胞成分，以及大汗腺内的原位癌。细胞表达GATA3、巨大囊肿病液体蛋白15、雄激素受体和E-钙黏蛋白。雌激素受体、孕激素受体和人表皮生长因子受体2均为阴性。需要进行临床关联以排除乳腺或胃肠道转移。尽管大多数皮肤大汗腺癌行为并不侵袭性，但我们的患者发生了骨转移，最终死于该疾病。组织细胞样和印戒细胞皮肤癌是否应归类为大汗腺肿瘤仍存在争议。与这种肿瘤相关的原位癌的存在在文献中仅被报道过一次。这一特征和免疫组化特征支持大汗腺分化。
